Long non-coding RNA: An underlying bridge linking neuroinflammation and central nervous system diseases. (September 2021)

• Record Type: Journal Article
• Authors: Chen, Zhuohui; Wu, Haiyue; Zhang, Mengqi
• Is Part Of: Neurochemistry international. Volume 148(2021)
• Publication Date: 2021-09
• Subjects: Long non-coding RNAs -- Neuroinflammation -- Central nervous system -- Microglia -- Astrocyte -- Therapeutic targets; Neurochemistry -- Periodicals; Neurochemistry -- Periodicals; Neurochimie -- Périodiques; Neurochemistry; Periodicals; 612.804205
• DOI: 10.1016/j.neuint.2021.105101
• Languages: English
• ISSNs: 0197-0186

Abstract

Abstract: Central nervous system (CNS) diseases are responsible for a large proportion of morbidity and mortality worldwide. CNS diseases caused by intrinsic and extrinsic stimuli stimulate the resident immune cells including microglia and astrocyte, resulting in neuroinflammation that exacerbates the progression of diseases. Recent evidence reveals the aberrant expression patterns of long non-coding RNAs (lncRNAs) in the damaged tissues following CNS diseases. It was also proposed that lncRNAs possessed immune-modulatory activities by directly or indirectly affecting various effector proteins including transcriptional factor, acetylase, protein kinase, phosphatase, etc. In addition, lncRNAs can form a sophisticated network by interacting with other molecules to regulate the expression or activation of downstream immune response pathways. However, the major roles of lncRNAs in CNS pathophysiologies are still elusive, especially in neuroinflammation. Herein, we tend to review some potential roles of lncRNAs in modulating neuroinflammation based on current evidence in various CNS diseases, in order to provide novel explanations for the initiation and progression of CNS diseases and help to establish therapeutic strategies targeting neuroinflammation. Highlights: Current studies highlighted inflammation as key pathologies in each CNS diseases LncRNAs play pivotal roles in neuroinflammation via targeting microglia and astrocyte LncRNAs mediate neuroinflammation mainly through affecting transcriptional, post-transcriptional and post-translational pathways in different CNS pathologies Neuroinflammation associated lncRNAs act as therapeutic targets and prognostic factors in CNS diseases