Aqueous metal-free hydrothiolation of enamides and enecarbamates. Issue 34 (22nd August 2019)

• Record Type: Journal Article
• Authors: Barman, Eliezer; Hourizadeh, Jason; Lim, Daniel
• Is Part Of: Tetrahedron letters. Volume 60:Issue 34(2019)
• Publication Date: 2019-08-22
• Subjects: Metal-free -- Hydrothiolation -- Anti-markovnikov -- Thiol-Ene; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.150951
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient and metal-free thiol-ene reaction. Anti-Markovnikov selective thiole-ene reaction. Hydrothioaltion reaction of enamides and enecarbamates in an aqueous medium is presented. This protocol is operationally simple, mild, and atom-economical. This process provides access to thioethers from available thiols and a variety of enamides and enecarbamates. Abstract: An efficient and metal-free, anti-Markovnikov selective, hydrothioaltion reaction of enamides and enecarbamates in an aqueous medium is presented. This protocol is operationally simple, mild, and atom-economical. This process provides access to thioethers from available thiols and a variety of enamides and enecarbamates.