Sensory processing and P300 event-related potential correlates of stimulant response in children with attention-deficit/hyperactivity disorder: A critical review. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Peisch, Virginia; Rutter, Tara; Wilkinson, Carol L.; Arnett, Anne B.
• Is Part Of: Clinical neurophysiology. Volume 132:Issue 4(2021)
• Page Start: 953
• Page End: 966
• Publication Date: 2021-04
• Subjects: ADHD -- Pediatric -- ERP -- Pharmacological treatment -- Biomarker; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2021.01.015
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: There are individual differences in stimulant response among children with attention-deficit/hyperactivity disorder (ADHD). Scalp electrophysiology may be used to predict ADHD treatment response. Stimulants appear to normalize the action preparation phase of attention processing. Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with considerable impairment in psychiatric and functional domains. Although stimulant medication can reduce core symptoms of inattention, hyperactivity, and impulsivity, a subgroup of patients does not respond to this intervention. A precision medicine approach has been proposed, whereby biomarkers are used to identify an effective treatment approach for a given individual. This review synthesizes the existing literature on event-related potential (ERP) correlates of stimulant response in children diagnosed with ADHD, with the goal of evaluating the potential for ERP to inform precision medicine care in this population. Forty-three articles were examined and results tentatively suggest that stimulant medications normalize the amplitude of the P300 component, and this is also associated with behavioral improvement. In contrast, results generally indicate that stimulants do not significantly alter early processing components, although there are some exceptions to this finding. Implications for research, theory, and clinical work are considered and concrete recommendations for future directions are provided. While recognizing limitations of existing literature (e.g., homogenous samples, variable methodologies), we conclude that ERP methods represent a promising approach for precision medicine care of patients with ADHD.