Cytochalasins D1 and C1, unique cytochalasans from endophytic fungus Xylaria cf. curta. Issue 34 (22nd August 2019)

• Record Type: Journal Article
• Authors: Wang, Wen-Xuan; Feng, Tao; Li, Zheng-Hui; Li, Jing; Ai, Hong-Lian; Liu, Ji-Kai
• Is Part Of: Tetrahedron letters. Volume 60:Issue 34(2019)
• Publication Date: 2019-08-22
• Subjects: Xylaria curta -- Cytochalasans -- Structural elucidation -- Cytotoxicity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.150952
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Two cytochalasans with oxygen bridged macrocycle identified from endophytic Xylaria cf. curta . Their structures were determined by 1D/2D NMR, ECD calculation and GIAO 13 C NMR calculation. They showed moderate cytotoxicity against human leukemia cell line HL-60. Abstract: Cytochalasins D1 (1 ) and C1 (2 ) were isolated from the liquid fermentation of fungus Xylaria cf. curta . Their structures and absolute configurations were determined by comprehensive experimental spectroscopic methods as well as ECD and GIAO 13 C NMR calculation. They possess a unique eleven-membered macrocycle with an oxygen bridge. Cytochalasins D1 and C1 showed moderate cytotoxicity against human leukemia cell lines HL-60 with IC50 value of 12.7 and 22.3 μM, respectively.