NEUROlogical Prognosis After Cardiac Arrest in Kids (NEUROPACK) study: protocol for a prospective multicentre clinical prediction model derivation and validation study in children after cardiac arrest. Issue 9 (25th September 2020)

• Record Type: Journal Article
• Authors: Scholefield, Barnaby Robert; Martin, James; Penny-Thomas, Kate; Evans, Sarah; Kool, Mirjam; Parslow, Roger; Feltbower, Richard; Draper, Elizabeth S; Hiley, Victoria; Sitch, Alice J; Kanthimathinathan, Hari Krishnan; Morris, Kevin P; Smith, Fang
• Other Names: author non-byline.; Thorburn Kent author non-byline.; Saxena Rohit author non-byline.; Thiru Yamuna author non-byline.; Levin Richard author non-byline.; Agbecko Rachel author non-byline.; Thiruchelvam Timothy author non-byline.; Skellett Sophie author non-byline.; Inwald David author non-byline.; Weitz James author non-byline.; Deep Akash author non-byline.; Cooper Sian author non-byline.; Barry Peter author non-byline.; Davies Patrick author non-byline.; Breatnach Cormac author non-byline.; Gala-Peralta Sandra author non-byline.; Lo Milly author non-byline.; Barber Rachael author non-byline.; Reid Stewart author non-byline.; Thomas Rum author non-byline.; Pappachan John author non-byline.; Dwarakanathan Buvana author non-byline.; Oruganti Siva author non-byline.; Sadasivam Kalai author non-byline.; Bebbington Mark author non-byline.
• Is Part Of: BMJ open. Volume 10:Issue 9(2020)
• Publication Date: 2020-09-25
• Subjects: paediatric intensive & critical care -- protocols & guidelines; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-037517
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Currently, we are unable to accurately predict mortality or neurological morbidity following resuscitation after paediatric out of hospital (OHCA) or in-hospital (IHCA) cardiac arrest. A clinical prediction model may improve communication with parents and families and risk stratification of patients for appropriate postcardiac arrest care. This study aims to the derive and validate a clinical prediction model to predict, within 1 hour of admission to the paediatric intensive care unit (PICU), neurodevelopmental outcome at 3 months after paediatric cardiac arrest. Methods and analysis: A prospective study of children (age: >24 hours and <16 years), admitted to 1 of the 24 participating PICUs in the UK and Ireland, following an OHCA or IHCA. Patients are included if requiring more than 1 min of cardiopulmonary resuscitation and mechanical ventilation at PICU admission Children who had cardiac arrests in PICU or neonatal intensive care unit will be excluded. Candidate variables will be identified from data submitted to the Paediatric Intensive Care Audit Network registry. Primary outcome is neurodevelopmental status, assessed at 3 months by telephone interview using the Vineland Adaptive Behavioural Score II questionnaire. A clinical prediction model will be derived using logistic regression with model performance and accuracy assessment. External validation will be performed using the Therapeutic Hypothermia After Paediatric Cardiac Arrest trial dataset. We aim to identify 370 patients, with successful consent and follow-up of 150 patients. Patient inclusion started 1 January 2018 and inclusion will continue over 18 months. Ethics and dissemination: Ethical review of this protocol was completed by 27 September 2017 at the Wales Research Ethics Committee 5, 17/WA/0306. The results of this study will be published in peer-reviewed journals and presented in conferences. Trial registration number: NCT03574025 .