Prevalence and genotype distribution of cervical human papilomavirus infection in the pre-vaccination era: a population-based study in the Canary Islands. Issue 9 (24th September 2020)

• Record Type: Journal Article
• Authors: Andujar, Miguel; Roura, Esther; Torres, Alejandra; Vega, Begoña; Pavcovich, Marta; Sanchez, Miguel Angel; Lubrano, Amina; Trujillo, Jose Luis; Almeida, Lucia; Santana, Milagros; Hurtado, Rosaura; Arencibia, Octavio; Benito, Virginia; Medina, Norberto; Carballo, Sonia; Camacho, Maria del Carmen; Ruiz del Pozo, Arancha; Quesada, Alfoso; Salido, Eduardo; de Sanjosé, Silvia; Bruni, Laia
• Other Names: author non-byline.; Alemán Diana author non-byline.; Almeida Mónica author non-byline.; Arencibia Ana María author non-byline.; Armas María Isabel author non-byline.; Batista Guillermina author non-byline.; Bernal Victoria author non-byline.; Quirós Francisca Bernaldo de author non-byline.; Bolaños Sili author non-byline.; Casaña Dolores author non-byline.; Celedón Luisa author non-byline.; Cruz Isabel author non-byline.; Díaz Elisa author non-byline.; Duarte Inocencia author non-byline.; Expósito Felisa author non-byline.; Felipe Carmelo author non-byline.; Galván Carlos author non-byline.; García María José author non-byline.; García María Isabel author non-byline.; García Vanesa author non-byline.; García Virginia author non-byline.; Giménez Elena author non-byline.; Godoy Teresa author non-byline.; Gómez Catalina author non-byline.; González Lucia author non-byline.; Gutiérrez Luisa author non-byline.; Hernández Mónica author non-byline.; Herrera Delia author non-byline.; Herrera Laura author non-byline.; Laseca Rosario author non-byline.; Marrero Carmen author non-byline.; Marrero Ofelia author non-byline.; Mateos Noa author non-byline.; Medina Olivia author non-byline.; Mendoza Josefa author non-byline.; Montesdeoca Lucia author non-byline.; Monzón Rosa author non-byline.; Morales Cristina author non-byline.; Morales Mercedes author non-byline.; Navarro M Dolores author non-byline.; Nieto María Ángeles author non-byline.; Pérez Noelia author non-byline.; Pérez Yurena author non-byline.; Ramos Antonio author non-byline.; Rico Antonio author non-byline.; Roldán Margarita author non-byline.; Salamanca Esther author non-byline.; Sánchez Rosario author non-byline.; Santana Raquel author non-byline.; Santos Elvira author non-byline.; Solanes Antonia author non-byline.; Soutto Elisabeth author non-byline.; Suarez Dulce author non-byline.; Suárez María Jesús author non-byline.; Tadeo María Ángeles author non-byline.; Valdés Virgen author non-byline.; Valido Gabriela author non-byline.; Vega Iralla author non-byline.; Vega Maria del Pino author non-byline.; Afonso María Angeles author non-byline.; Baena Elisa author non-byline.; Baz María Pilar author non-byline.; Armas José de author non-byline.; Puerta Alicia de la author non-byline.; García Josefina author non-byline.; González María Asuncion author non-byline.; González Célida author non-byline.; Hernández María Teresa author non-byline.; Limiñana Josefa author non-byline.; León Carmen Rosa author non-byline.; Marín Fernando author non-byline.; Manrique Emma author non-byline.; Negrín José Roberto author non-byline.; Olavarrieta Rosa author non-byline.; Perera Verónica author non-byline.; Sabater Concepción author non-byline.; Sosvilla Candelaria author non-byline.;
• Is Part Of: BMJ open. Volume 10:Issue 9(2020)
• Publication Date: 2020-09-24
• Subjects: cytopathology -- gynaecological oncology -- epidemiology -- infectious diseases; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-037402
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: National Spanish studies show that prevalence of cervical human papillomavirus (HPV) infection in the female population is increasingly frequent, with an overall estimate of 14% in women aged 18–65 years. The objective of this study is to know the prevalence and distribution of HPV types in the female population of the Canary Islands prior to the introduction of HPV vaccines and to investigate the associated clinical and sociodemographic factors. Methods: Based on the Primary Health Care database, a sample of adult women (aged 18–65 years) of Gran Canaria (GC) and Tenerife (TF) stratified into nine age groups was carried out between 2002 and 2007. Women were contacted by postal letter and telephone call and were visited in their primary care centre. A clinical-epidemiological survey was completed and cervical samples were taken for cytological study and HPV detection. HPV prevalence and its 95% CI were estimated, and multivariate analyses were performed using logistic regression to identify factors associated with the infection. Results: 6010 women participated in the study, 3847 from GC and 2163 from TF. The overall prevalence of HPV infection was 13.6% (CI 12.8%–14.5%) and 11.1% (CI 10.3%–11.9%) for high-risk types. The most frequent HPV type was 16 followed by types 51, 53, 31, 42 and 59. HPV types included in the nonavalent vaccine were detected in 54.1% of infected women. Factors associated with an increased risk of infection were: young ages (18–29 years), the number of sexual partners throughout life, not being married, being a smoker, and having had previous cervical lesions or genital warts. Conclusions: It is confirmed that prevalence of HPV infection in the female population of the Canary Islands is high, but similar to that of Spain, HPV 16 being the most frequent genotype. The determinants of infection are consistent with those of other populations.