Non‐motor symptom burden is strongly correlated to motor complications in patients with Parkinson's disease. (24th April 2020)

• Record Type: Journal Article
• Authors: Santos‐García, D.; de Deus Fonticoba, T.; Suárez Castro, E.; Aneiros Díaz, A.; McAfee, D.; Catalán, M. J.; Alonso‐Frech, F.; Villanueva, C.; Jesús, S.; Mir, P.; Aguilar, M.; Pastor, P.; García Caldentey, J.; Esltelrich Peyret, E.; Planellas, L. L.; Martí, M. J.; Caballol, N.; Hernández Vara, J.; Martí Andrés, G.; Cabo, I.; Ávila Rivera, M. A.; López Manzanares, L.; Redondo, N.; Martinez‐Martin, P.; McAfee, D.
• Other Names: Astrid Adarmes Daniela investigator.; Almeria Marta investigator.; Alonso Losada Maria Gema investigator.; Alonso Cánovas Araceli investigator.; Álvarez Sauco María investigator.; Arnáiz Sandra investigator.; Arribas Sonia investigator.; Ascunce Vidondo Arancha investigator.; Bernardo Lambrich Noemí investigator.; Bejr‐Kasem Helena investigator.; Blázquez Estrada Marta investigator.; Botí González Maria Ángeles investigator.; Borrué Carmen investigator.; Cabello González Carolina investigator.; Cámara Lorenzo Ana investigator.; Carrillo Fátima investigator.; Carrillo Padilla Francisco José investigator.; Casas Elena investigator.; Clavero Pedro investigator.; Cortina Fernández A. investigator.; Cots Foraster Anna investigator.; Crespo Cuevas Ane investigator.; Cubo Esther investigator.; De Fábregues‐Boixar Oriol investigator.; Díez Fairen M. investigator.; Erro Elena investigator.; Escalante Sonia investigator.; Fernández Guillán Noelia investigator.; Gámez Pedro investigator.; Gallego Mercedes investigator.; García Campos Cristina investigator.; García Moreno Jose Manuel investigator.; Gastón Itziar investigator.; Gómez Garre María del Pilar investigator.; González Aloy Javier investigator.; González Aramburu Isabel investigator.; González Ardura Jessica investigator.; González García Beatriz investigator.; González Palmás Maria Josefa investigator.; González Toledo Gabriel Ricardo investigator.; Golpe Díaz Ana investigator.; Grau Solá Mireia investigator.; Guardia Gemma investigator.; Horta Barba Andrea investigator.; Infante Jon investigator.; Kulisevsky Jaime investigator.; Kurtis Mónica investigator.; Labandeira Carmen investigator.; Labrador Espinosa Miguel Ángel investigator.; Lacruz Francisco investigator.; Lage Castro Melva investigator.; Legarda Inés investigator.; López Ariztegui N. investigator.; López Díaz Luis Manuel investigator.; López Seoane Balbino investigator.; Macías Yolanda investigator.; Mata Marina investigator.; Martínez Castrillo Juan Carlos investigator.; Meitín Maria Teresa investigator.; Menéndez González Manuel investigator.; Méndez del Barrio Carlota investigator.; Miranda Santiago Javier investigator.; Morales Casado Maria Isabel investigator.; Moreno Diéguez Antonio investigator.; Nogueira Víctor investigator.; Novo Amado Alba investigator.; Novo Ponte Sabela investigator.; Ordás Carlos investigator.; Pagonabarraga Javier investigator.; Isabel Pareés investigator.; Pascual‐Sedano Berta investigator.; Pérez Fuertes Aída investigator.; Pérez Noguera Rafael investigator.; Prats Marian Ángeles investigator.; Prieto Jurczynska Cristina investigator.; Puente Víctor investigator.; Pueyo Morlans Mercedes investigator.; Rodríguez Méndez Luisa investigator.; Rodríguez Pérez Amparo Belén investigator.; Roldán Florinda investigator.; Ruíz de Arcos María investigator.; Ruíz Martínez Javier investigator.; Sánchez Alonso Pilar investigator.; Sánchez‐Carpintero Macarena investigator.; Sánchez Díez Gema investigator.; Sánchez Rodríguez Antonio investigator.; Santacruz Pilar investigator.; Segundo Rodríguez José Clemente investigator.; Seijo Manuel investigator.; Serarols Agustí investigator.; Sierra María investigator.; Solano Berta investigator.; Tartari Juan Pablo investigator.; Valero Caridad investigator.; Vargas Laura investigator.; Vázquez Gómez Ricardo investigator.; Vela Lydia investigator.; Vives Bárbara investigator.; Villa Maria Dolores investigator.;
• Is Part Of: European journal of neurology. Volume 27:Number 7(2020)
• Page Start: 1210
• Page End: 1223
• Publication Date: 2020-04-24
• Subjects: dyskinesia -- fatigue -- motor fluctuations -- non‐motor symptoms -- Parkinson's disease; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14221
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: The objective of this study was to analyze the relationship between motor complications and non‐motor symptom (NMS) burden in a population of patients with Parkinson's disease (PD) and also in a subgroup of patients with early PD. Methods: Patients with PD from the COPPADIS cohort were included in this cross‐sectional study. NMS burden was defined according to the Non‐Motor Symptoms Scale (NMSS) total score. Unified Parkinson's Disease Rating Scale (UPDRS) part IV was used to establish motor complication types and their severity. Patients with ≤5 years of symptoms from onset were included as patients with early PD. Results: Of 690 patients with PD (62.6 ± 8.9 years old, 60.1% males), 33.9% and 18.1% presented motor fluctuations and dyskinesia, respectively. The NMS total score was higher in patients with motor fluctuations (59.2 ± 43.1 vs. 38.3 ± 33.1; P < 0.0001) and dyskinesia (63.5 ± 40.7 vs. 41.4 ± 36.3; P < 0.0001). In a multiple linear regression model and after adjustment for age, sex, disease duration, Hoehn & Yahr stage, UPDRS‐III score and levodopa equivalent daily dose, UPDRS‐IV score was significantly related to a higher NMSS total score ( β = 0.27; 95% confidence intervals, 2.81–5.61; P < 0.0001), as it was in a logistic regression model on dichotomous NMSS total score (≤40, mild or moderate vs. >40, severe or very severe) (odds ratio, 1.31; 95% confidence intervals, 1.17–1.47; P < 0.0001). In the subgroup of patients with early PD ( n = 396; mean disease duration 2.7 ± 1.5 years), motor fluctuations were frequent (18.1%) and similar results were obtained. Conclusions: Motor complications were frequent and were associated with a greater NMS burden in patients with PD even during the first 5 years of disease duration.