Assessing false paternity risk in simulated motherless cases from more than 20 000 real exclusion trios. Issue 3 (21st October 2020)

• Record Type: Journal Article
• Authors: Aguiar, Vitor R. C.; de Castro, Amanda M.; Pinto, Laélia M.; Ferreira, Alessandro C. S.; dos Santos, Eldamária V. W.; Louro, Iuri D.
• Is Part Of: Transfusion. Volume 61:Issue 3(2021)
• Page Start: 678
• Page End: 681
• Publication Date: 2020-10-21
• Subjects: deficient paternity -- duo -- false inclusion -- motherless -- paternity -- STR loci; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.16153
• Languages: English
• ISSNs: 0041-1132

Abstract

Abstract: Background: When the motherʼs DNA profile is not available for paternity testing, there is a smaller probability that a locus will exclude an alleged father. This study aims to evaluate the risk of potential false paternity inclusions in motherless cases. Study Design and Methods: More than 20 000 duos were generated by removing the maternal genotypes from exclusion trios. After recalculating paternity in these duos, any found inclusions would be false. Results: The use of an appropriate number of loci, mutation model, and mutation rates to analyze motherless paternity cases was robust against false inclusions. A single potential false inclusion was observed in a case wherein kinship plays a role. This result highlights the importance of testing the mother when available and of obtaining information on family circumstances for the proper handling of cases involving related individuals. Conclusion: The guidelines we used here were sufficient to avoid false inclusions in a data set of more than 20 000 motherless cases.