External validation and recalibration of an incidental meningioma prognostic model – IMPACT: protocol for an international multicentre retrospective cohort study. Issue 1 (18th January 2022)

• Record Type: Journal Article
• Authors: Islim, Abdurrahman I; Millward, Christopher P; Piper, Rory J; Fountain, Daniel M; Mehta, Shaveta; Kolamunnage-Dona, Ruwanthi; Ali, Usama; Koszdin, Shelli Diane; Georgious, Theo; Mills, Samantha J; Brodbelt, Andrew R; Mathew, Ryan K; Santarius, Thomas; Jenkinson, Michael D
• Other Names: author non-byline.; Abdelsadg Mohamed author non-byline.; Abualsaud Suhaib author non-byline.; Abuleil Amro author non-byline.; Agyemang Kevin author non-byline.; Akbari Hanan author non-byline.; Alakandy Likhith author non-byline.; Albanese Erminia author non-byline.; Alfonso Clarissa author non-byline.; Ali Usama author non-byline.; Ali Arousa author non-byline.; Ali Tamara author non-byline.; Amoo Michael author non-byline.; Arbab Mohamed A. R. author non-byline.; Asha Mutiu author non-byline.; Austin Kareem author non-byline.; Badran Khaled author non-byline.; Bal Jarnail author non-byline.; Barrett Chris author non-byline.; Bhattathiri Parameswaran author non-byline.; Brennan Paul M. author non-byline.; Brodbelt Andrew R. author non-byline.; Brown Jennifer author non-byline.; Brown Daniel author non-byline.; Brugada-Bellsolà Ferran author non-byline.; Bruzzaniti Placido author non-byline.; Butcher Annabel author non-byline.; Cairns Rory S. author non-byline.; Canty Michael author non-byline.; Cearns Michael author non-byline.; Chakravarti Sachiv author non-byline.; Chave-Cox Rebecca author non-byline.; Chowdhury Yasir author non-byline.; Craig-McQuade Anna author non-byline.; Critchley Giles author non-byline.; Crossley Peter author non-byline.; Culpin Elizabeth author non-byline.; D'Amico Alessia author non-byline.; Dabbous Bassam author non-byline.; Delgado-López Pedro David author non-byline.; Draz Mohamed author non-byline.; Drummond Katharine J. author non-byline.; Ekanayaka Rusiru T. author non-byline.; Elhadi Muhammed author non-byline.; Elmaadawi Ibrahim author non-byline.; Elmandouh Omar author non-byline.; Elsharif Mazin author non-byline.; Evans Daisy author non-byline.; Fahlström Andreas author non-byline.; Familiari Pietro author non-byline.; Fisher Fleur L. author non-byline.; Ford Bryony author non-byline.; Fountain Daniel M. author non-byline.; Fox Keiko author non-byline.; Gaillard Francesco author non-byline.; Gelder Chloé author non-byline.; Georgious Theo author non-byline.; Ghosh Shamayitri author non-byline.; Goel Aimee author non-byline.; Gough Melissa author non-byline.; Grivas Athanasios author non-byline.; Gvozdanovic Andrew author non-byline.; Hall Allan author non-byline.; Hamid Hytham author non-byline.; Hartrick Liv author non-byline.; Hassan Samih author non-byline.; Henry Jack author non-byline.; Holliman Damian author non-byline.; Islim Abdurrahman I. author non-byline.; Jakola Asgeir S. author non-byline.; Javadpour Mohsen author non-byline.; Jenkinson Michael D. author non-byline.; Jeyaretna Sanjeeva author non-byline.; Jimenez Adrian author non-byline.; Jung Josephine author non-byline.; Kahramanian Andranik author non-byline.; Kalra Neeraj author non-byline.; Kamson David O. author non-byline.; Kennion Oliver author non-byline.; Khalafallah Adham M. author non-byline.; Kingdon Sarah author non-byline.; Kolamunnage-Dona Ruwanthi author non-byline.; Koszdin Shelli Diane author non-byline.; Ktayen Howra author non-byline.; Kumar Aditaya author non-byline.; Lammy Simon author non-byline.; Lapolla Pierfrancesco author non-byline.; Lau Jun Yi author non-byline.; Lee Jing Xian author non-byline.; Leyden Ryan author non-byline.; Littlechild Patricia author non-byline.; Liu Sophie author non-byline.; Lora-Kay Darmanin author non-byline.; Lung Vivia author non-byline.; Magill Stephen T. author non-byline.; Marcus Hani J. author non-byline.; Marhoom Fawaz E. author non-byline.; Martin-Alonso Javier author non-byline.; Mathew Ryan K. author non-byline.; Mathieson Calan author non-byline.; McSorley Nathan author non-byline.; Mederer Tobias author non-byline.; Mehta Shaveta author non-byline.; Meling Torstien R. author non-byline.; Mills Samantha J. author non-byline.; Millward Christopher P. author non-byline.; Mingoli Andrea author non-byline.; Mohammad Mujtaba author non-byline.; Mukherjee Debraj author non-byline.; Zamanipoor Najafabadi Amir H. author non-byline.; Näslund Olivia author non-byline.; Nguyen Minh author non-byline.; Noorani Imran author non-byline.; Patet Gildas author non-byline.; Pathmanaban Omar N. author non-byline.; Perera Andrea author non-byline.; Persad Amit author non-byline.; Phang See Yung author non-byline.; Piper Rory J. author non-byline.; Pollock Jonathan author non-byline.; Price Benjamin author non-byline.; Proescholdt Martin author non-byline.; Pullicino Richard author non-byline.; Robins James author non-byline.; Rominiyi Ola author non-byline.; Rowland David author non-byline.; Sachdev Bobby author non-byline.; Saeed Fozia author non-byline.; Saleh Mahmoud author non-byline.; Santarius Thomas author non-byline.; Santoro Antonio author non-byline.; Sataite Ieva author non-byline.; Scafa Antony Kevin author non-byline.; Schadewaldt Verena author non-byline.; Shah Syed Wajahat author non-byline.; Sheikh Mustafa El author non-byline.; Sher Zenab author non-byline.; Skeie Bente Sandvei author non-byline.; Smedley Alexander author non-byline.; Sofela Agbolahan author non-byline.; George Jerome St author non-byline.; Strømsnes Torbjørn author non-byline.; Suttner Nigel author non-byline.; Taylor William author non-byline.; Theodosopoulos Philip author non-byline.; Tilling Elliot author non-byline.; Tripathi Manjul author non-byline.; Ughratdar Ismail author non-byline.; Ulrich James author non-byline.; Varma Adithya author non-byline.; Varma Anil author non-byline.; Velicu Maria author non-byline.; Venturini Sara author non-byline.; Wu Esther author non-byline.; Young Jacob author non-byline.; Zancana Giuseppa author non-byline.; Zhang Catherine author non-byline.; Au Karolyn author non-byline.; Barnholtz-Sloan Jill author non-byline.; Behling Felix author non-byline.; Bi Linda author non-byline.; Brastianos Priscilla author non-byline.; Brodie Chaya author non-byline.; Butowski Nicholas author non-byline.; Castro Ana author non-byline.; Cohen-Gadol Aaron author non-byline.; Couce Marta author non-byline.; Dimeco Francesco author non-byline.; Drummond Katherine J. author non-byline.; Dunn Ian author non-byline.; Erker Craig author non-byline.; Felicella Michelle author non-byline.; Fountain Daniel M. author non-byline.; Galanis Eva author non-byline.; Galldiks Norbert author non-byline.; Giannini Caterina author non-byline.; Goldbrunner Roland author non-byline.; Hanemann Oliver author non-byline.; Herold-Mende Christel author non-byline.; Hnenny Luke author non-byline.; Horbinski Craig author non-byline.; Huang Raymond author non-byline.; Islim Abdurrahman I. author non-byline.; Javadpour Mohsen author non-byline.; Jenkinson Michael D. author non-byline.; Jungk Christine author non-byline.; Jungwirth Gerhard author non-byline.; Kaufmann Timothy author non-byline.; Krischek Boris author non-byline.; Kurz Sylvia author non-byline.; Lachance Daniel author non-byline.; Lafougere Christian author non-byline.; Lamszus Katrin author non-byline.; Makarenko Serge author non-byline.; Malta Tathiana author non-byline.; Mathiesen Tiit Illimar author non-byline.; Mawrin Christian author non-byline.; McDermott Michael author non-byline.; Millward Christopher P. author non-byline.; Moliterno-Gunel Jennifer author non-byline.; Morokoff Andrew author non-byline.; Nassiri Farshad author non-byline.; Ng HK author non-byline.; Noushmehr Houtan author non-byline.; Pathmanaban Omar N. author non-byline.; Perry Arie author non-byline.; Poisson Laila author non-byline.; Pollo Bianco author non-byline.; Ragunathan Aditya author non-byline.; Raleigh David author non-byline.; Renovanz Mirjam author non-byline.; Ricklefs Franz author non-byline.; Sahm Felix author non-byline.; Saladino Andrea author non-byline.; Santacroce Antonio author non-byline.; Santarius Thomas author non-byline.; Schichor Christian author non-byline.; Schimdt Nils author non-byline.; Schittenhelm Jens author non-byline.; Selman Warren author non-byline.; Shih Helen author non-byline.; Sloan Andrew author non-byline.; Snuderl Matija author non-byline.; Snyder Jim author non-byline.; Sulman Erik author non-byline.; Suppiah Suganth author non-byline.; Tabatabai Ghazaleh author non-byline.; Tatagiba Marcos author non-byline.; Timmer Marco author non-byline.; Tonn Jorg-Christian author non-byline.; Vogelbaum Michael author non-byline.; Deimling Andreas Von author non-byline.; Walbert Tobias author non-byline.; Walling Simon author non-byline.; Wang Justin Z. author non-byline.; Wen Patrick author non-byline.; Westphal Manfred author non-byline.; Yip Stephen author non-byline.; Zada Gabriel author non-byline.; Zadeh Gelareh author non-byline.; Zherebitskiy Viktor author non-byline.; Fountain Daniel M. author non-byline.; Poon Michael T.C. author non-byline.; Kolias Angelos author non-byline.; Woodfield Julie author non-byline.; Piper Rory author non-byline.; Chari Aswin author non-byline.; Islim Abdurrahman I. author non-byline.; Kalra Neeraj author non-byline.;
• Is Part Of: BMJ open. Volume 12:Issue 1(2022)
• Publication Date: 2022-01-18
• Subjects: neurological oncology -- neurosurgery -- neuroradiology -- oncology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-052705
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. Methods and analysis: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. Ethics and dissemination: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-reviewed articles and conferences and disseminated to participating centres, patients and the public using social media.