DETECTION OF TRANSGENERATIONAL GENETIC EFFECTS BASED ON WHOLE-GENOME SEQUENCING IN THE MOUSE MODEL. Issue 13 (9th September 2022)

• Record Type: Journal Article
• Authors: Gondo, Yoichi
• Is Part Of: Radiation protection dosimetry. Volume 198:Issue 13/15(2022)
• Page Start: 1137
• Page End: 1142
• Publication Date: 2022-09-09
• Subjects: Radiation dosimetry -- Periodicals; Radiation -- Safety measures -- Periodicals; 363.1799
• DOI: 10.1093/rpd/ncac079
• Languages: English
• ISSNs: 0144-8420

Abstract

Abstract: It has become feasible to detect de novo mutations in mammalian genomes by using whole-genome sequencing. The power to detect numbers of de novo mutations should provide a useful tool to assess the transgenerational genetic effects of radiations on living organisms. By reviewing the spontaneous mutations in the mouse as a model, an action plan is proposed to detect the induced mutations after accumulating mutations for several generations with continuous exposure to low-dose radiations. Some susceptibility differences against radiations between humans and model animals for the transgenerational effect have been suggested. The applicability of the mouse model for the assessment of low-dose radiation is also discussed.