C-reactive protein in early-onset neonatal sepsis – a cutoff point for CRP value as a predictor of early-onset neonatal sepsis in term and late preterm infants early after birth?. (2nd December 2022)

• Record Type: Journal Article
• Authors: Yochpaz, Sivan; Friedman, Nati; Zirkin, Semyon; Blumovich, Amit; Mandel, Dror; Marom, Ronella
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 23(2022)
• Page Start: 4552
• Page End: 4557
• Publication Date: 2022-12-02
• Subjects: Early-onset neonatal sepsis -- C-reactive protein -- late preterm infants; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2020.1856068
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To identify whether the first plasma C-reactive protein values taken 6–8 h postpartum are predictive of the clinical early-onset neonatal sepsis (cEONS). Study design: We retrospectively analyzed C-reactive protein (CRP) values of 400 neonates, including 28 with cEONS, who underwent plasma CRP measurements as part of sepsis work-up. To determine whether the first CRP measurement is predictive of cEONS, logistic regression was used with CRP as an independent variable and cEONS (yes/no) as a dependent variable. Result: A moderate predictive ability of the first CRP measurement (odds ratio 1.4, CI: [1.13, 1.76], p =.003) was revealed, at a 5.3 mg/L threshold. However, it resulted in poor sensitivity of 50%, and a false positive rate of 30%. Increasing the sensitivity to 75% or 90% lead to increased false-positive rates of 55% and 75%, respectively. Conclusions: Our findings suggest that the first CRP value taken in neonates is a weak predictor of cEONS.