Metal‐Free and Open‐Air Arylation Reactions of Diaryliodonium Salts for DNA‐Encoded Library Synthesis (Adv. Sci. 26/2022). Issue 26 (15th September 2022)

• Record Type: Journal Article
• Authors: Xu, Hongtao; Tan, Tingting; Zhang, Yiyuan; Wang, Yan; Pan, Kangyin; Yao, Ying; Zhang, Shuning; Gu, Yuang; Chen, Wanting; Li, Jie; Dong, Hewei; Meng, Yu; Ma, Peixiang; Hou, Wei; Yang, Guang
• Is Part Of: Advanced science. Volume 9:Issue 26(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-15
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202270165
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Meeting Diaryliodonium salts Chemistry with DNA‐Encoded Library DNA‐encoded library (DEL) is a powerful technique for hit discovery in medicinal chemistry. In article number 2202790, Hongtao Xu, Peixiang Ma, Wei Hou, Guang Yang, and co‐workers develope the first on‐DNA meeting diaryliodonium salts (DAI) chemistry and realize the selective arylation of phenols and oximes with both high yield and DNA fidelity via substrate activation strategy.