An elevated platelet-to-lymphocyte ratio is associated with a higher risk of intracranial atherosclerotic stenosis. Issue 12 (20th June 2022)

• Record Type: Journal Article
• Authors: Huang, Yanhua; Wang, Zuoteng; Zhao, Bing; Ma, Yahui; Ou, Yanan; Hu, Hao; Hou, Xiaohe; Yu, Jintai; Tan, Lan
• Editors: Yin, Yanjie; Hao, Xiuyuan
• Is Part Of: Chinese medical journal. Volume 135:Issue 12(2022)
• Page Start: 1425
• Page End: 1431
• Publication Date: 2022-06-20
• Subjects: Platelet-to-lymphocyte ratio -- Intracranial atherosclerotic stenosis -- Atherosclerosis -- Inflammation; Medicine -- Periodicals; Medicine, Oriental -- Periodicals; Medicine; Medicine, Oriental; Medicine; Medicine, East Asian Traditional; Periodicals; Electronic journals; 610.5
• DOI: 10.1097/CM9.0000000000002228
• Languages: English
• ISSNs: 0366-6999

Abstract

Abstract: Background: Previous studies have shown that inflammation plays an important role in intracranial atherosclerotic stenosis (ICAS). The platelet-to-lymphocyte ratio (PLR) has recently emerged as a potential inflammatory biomarker. This study aimed to explore the association of the PLR with ICAS in a Chinese Han population. Methods: A total of 2134 participants (518 with ICAS, 1616 without ICAS) were enrolled in this study. ICAS was defined as atherosclerotic stenosis >50% or the occlusion of several main intracranial arteries. Multivariable logistic regression analyses were used to assess the association of the PLR with ICAS. Additional subgroup analyses were performed according to age (<60 vs. ≥60 years) and acute ischemic stroke. Results: Multivariate regression analysis showed that a high PLR was associated with a higher risk of ICAS in all participants ( P < 0.001). Compared with the lowest quartile, the fourth PLR quartile was significantly associated with ICAS (OR 1.705, 95% confidence interval 1.278–2.275, P < 0.001). In the subgroups stratified by age, an association between the PLR and ICAS was found in the late-life group ( P < 0.001), but not in the mid-life group ( P = 0.650). In the subgroups stratified by acute ischemic stroke, the relationship between an elevated PLR and a higher risk of ICAS remained unchanged (stroke group, P < 0.001; non-stroke group, P = 0.027). Conclusions: An elevated PLR was associated with a higher risk of ICAS in a Chinese Han population. The PLR might serve as a potential biomarker for ICAS in the elderly population.