Characteristics of recent clinical investigations into systemic therapy against cervical cancer: systematic analysis of trial details from Clinicaltrials.gov. (4th July 2022)

• Record Type: Journal Article
• Authors: Girma, Biniyam; Makonnen, Eyasu; Shibeshi, Workineh
• Is Part Of: Journal of obstetrics and gynaecology. Volume 42:Number 5(2022)
• Page Start: 793
• Page End: 801
• Publication Date: 2022-07-04
• Subjects: Clinical trials -- cervical cancer -- systemic therapy -- drug development -- clinicaltrials.gov; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.1080/01443615.2021.1980507
• Languages: English
• ISSNs: 0144-3615

Abstract

Abstract: A review that systematically assessed the current state of clinical research into systematic therapy-based interventions against invasive cervical cancer. It analysed registry details of 59 systemic therapy-based cervical cancer trials on ClinicalTrials.gov with study start dates between January 2010 and June 2018. The review characterised the present cervical cancer trial landscape in terms of trial design features, systemic therapy (chemotherapy, targeted therapy, immunotherapy, and repurposed therapy), and disease stages of interest. It also made an attempt to qualitatively synthesise the trial landscape in terms of the nature and trend of research focus, alignment with existing clinical needs, novelty of treatments or concepts pursued, and promise of new treatments.