Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities. Issue 5 (4th May 2022)

• Record Type: Journal Article
• Authors: Shahbazi, Foroud; Shojaei, Lida; Farvadi, Fakhrossadat; Kadivarian, Sara
• Is Part Of: Expert review of clinical pharmacology. Volume 15:Issue 5(2022)
• Page Start: 563
• Page End: 573
• Publication Date: 2022-05-04
• Subjects: Anti-infective agents -- fluid therapy -- Clostridioides difficile -- neurocognitive disorders -- hematologic toxicities; Clinical pharmacology -- Periodicals; 615.105
• DOI: 10.1080/17512433.2022.2093716
• Languages: English
• ISSNs: 1751-2433

Abstract

ABSTRACT: Introduction: Antibiotic prescription is a challenging issue in critical care settings. Different pharmacokinetic and pharmacodynamic properties, polypharmacy, drug interactions, and high incidence of multidrug-resistant microorganisms in this population can influence the selection, safety, and efficacy of prescribed antibiotics. Areas covered: In the current article we searched PubMed, Scopus and Google Scholar for neurotoxicities, hematologic toxicity and fluid stewardship in intensive care units. Expert opinion: Critically ill patients who receive antimicrobial agents should be monitored for neurological, hematologic toxicities especially seizure, thrombocytopenia, and clostridioides infections. Other toxicities including QTc prolongation, electrolyte disturbances, liver enzyme elevation, and infusion-related reactions were being considered. Other changes, including fluid overload, hypoalbuminemia, augmented renal clearance, increased cardiac outputs in septic shock, and acute kidney injury, may influence treatment efficiency and patient outcome.