Examination of Common Coronavirus Antibodies in SARS-CoV-2-Infected and Uninfected Participants in a Household Transmission Investigation. (20th July 2022)

• Record Type: Journal Article
• Authors: Stumpf, Megan M; Freeman, Brandi; Mills, Lisa; Lester, Sandra; Chu, Victoria T; Kirking, Hannah L; Thornburg, Natalie J; Killerby, Marie E
• Is Part Of: Open forum infectious diseases. Volume 9:Number 7(2022)
• Publication Date: 2022-07-20
• Subjects: common coronaviruses -- COVID-19 -- human coronaviruses -- immunology -- SARS-CoV-2; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac212
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We compared paired serum specimens from household contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases with detectable SARS-CoV-2 seroconversion with contacts who remained seronegative. No protection from SARS-CoV-2 infection was associated with human coronavirus antibodies; however, an increase in common betacoronavirus antibodies was associated with seroconversion to SARS-CoV-2 in mild to moderately ill cases.