Modelling articular cartilage: the relative motion of two adjacent poroviscoelastic layers. (9th June 2022)

• Record Type: Journal Article
• Authors: Whiteley, Jonathan P; Brown, Cameron P; Gaffney, Eamonn A
• Is Part Of: Mathematical medicine and biology. Volume 39:Number 3(2022)
• Page Start: 251
• Page End: 298
• Publication Date: 2022-06-09
• Subjects: cartilage -- poroviscoelasticity -- homogenization; Biomathematics -- Periodicals; Medicine -- Mathematics -- Periodicals; Medicine -- Periodicals; Biology -- Periodicals; Biomedical Research -- Periodicals; Models, Theoretical -- Periodicals; 570.15195
• DOI: 10.1093/imammb/dqac005
• Languages: English
• ISSNs: 1477-8599

Abstract

Abstract: In skeletal joints two layers of adjacent cartilage are often in relative motion. The individual cartilage layers are often modelled as a poroviscoelastic material. To model the relative motion, noting the separation of scales between the pore level and the macroscale, a homogenization based on multiple scale asymptotic analysis has been used in this study to derive a macroscale model for the relative translation of two poroviscoelastic layers separated by a very thin layer of fluid. In particular the fluid layer thickness is essentially zero at the macroscale so that the two poroviscoelastic layers are effectively in contact and their interaction is captured in the derived model via a set of interfacial conditions, including a generalization of the Beavers–Joseph condition at the interface between a viscous fluid and a porous medium. In the simplifying context of a uniform geometry, constant fixed charge density, a Newtonian interstitial fluid and a viscoelastic scaffold, modelled via finite deformation theory, we present preliminary simulations that may be used to highlight predictions for how oscillatory relative movement of cartilage under load influences the peak force the cartilage experiences and the extent of the associated deformations. In addition to highlighting such cartilage mechanics, the systematic derivation of the macroscale models will enable the study of how nanoscale cartilage physics, such as the swelling pressure induced by fixed charges, manifests in cartilage mechanics at much higher lengthscales.