MRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients . (6th April 2022)

• Record Type: Journal Article
• Authors: Kwon, Jennie H; Tenforde, Mark W; Gaglani, Manjusha; Talbot, H Keipp; Ginde, Adit A; McNeal, Tresa; Ghamande, Shekhar; Douin, David J; Casey, Jonathan D; Mohr, Nicholas M; Zepeski, Anne; Shapiro, Nathan I; Gibbs, Kevin W; Files, D Clark; Hager, David N; Shehu, Arber; Prekker, Matthew E; Caspers, Sean D; Exline, Matthew C; Botros, Mena; Gong, Michelle N; Li, Alex; Mohamed, Amira; Johnson, Nicholas J; Srinivasan, Vasisht; Steingrub, Jay S; Peltan, Ithan D; Brown, Samuel M; Martin, Emily T; Khan, Akram; Hough, Catherine L; Busse, Laurence W; Duggal, Abhijit; Wilson, Jennifer G; Perez, Cynthia; Chang, Steven Y; Mallow, Christopher; Rovinski, Randal; Babcock, Hilary M; Lauring, Adam S; Felley, Laura; Halasa, Natasha; Chappell, James D; Grijalva, Carlos G; Rice, Todd W; Womack, Kelsey N; Lindsell, Christopher J; Hart, Kimberly W; Baughman, Adrienne; Olson, Samantha M; Schrag, Stephanie; Kobayashi, Miwako; Verani, Jennifer R; Patel, Manish M; Self, Wesley H;
• Is Part Of: Journal of infectious diseases. Volume 226:Number 5(2022)
• Page Start: 797
• Page End: 807
• Publication Date: 2022-04-06
• Subjects: COVID-19 -- immunocompromised -- SARS-CoV-2 -- solid organ transplantation -- vaccine effectiveness; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac118
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: The study objective was to evaluate 2- and 3-dose coronavirus disease 2019 (COVID-19) mRNA vaccine effectiveness (VE) in preventing COVID-19 hospitalization among adult solid organ transplant (SOT) recipients. Methods: We conducted a 21-site case-control analysis of 10 425 adults hospitalized in March to December 2021. Cases were hospitalized with COVID-19; controls were hospitalized for an alternative diagnosis (severe acute respiratory syndrome coronavirus 2-negative). Participants were classified as follows: SOT recipient (n = 440), other immunocompromising condition (n = 1684), or immunocompetent (n = 8301). The VE against COVID-19-associated hospitalization was calculated as 1-adjusted odds ratio of prior vaccination among cases compared with controls. Results: Among SOT recipients, VE was 29% (95% confidence interval [CI], −19% to 58%) for 2 doses and 77% (95% CI, 48% to 90%) for 3 doses. Among patients with other immunocompromising conditions, VE was 72% (95% CI, 64% to 79%) for 2 doses and 92% (95% CI, 85% to 95%) for 3 doses. Among immunocompetent patients, VE was 88% (95% CI, 87% to 90%) for 2 doses and 96% (95% CI, 83% to 99%) for 3 doses. Conclusions: Effectiveness of COVID-19 mRNA vaccines was lower for SOT recipients than immunocompetent adults and those with other immunocompromising conditions. Among SOT recipients, vaccination with 3 doses of an mRNA vaccine led to substantially greater protection than 2 doses. Abstract : Effectiveness of COVID-19 mRNA vaccines against COVID-19 hospitalization is lower for solid organ transplant (SOT) recipients compared with immunocompetent people and those with other immunocompromising conditions. Among SOT recipients, 3 vaccine doses lead to substantially greater protection than 2.