Re-evaluating the merits of decentralization as a core strategy for effective delivery of drug-resistant tuberculosis care in Pakistan. Issue 8 (9th May 2022)

• Record Type: Journal Article
• Authors: Khan, Uzma; Lotia-Farrukh, Ismat; Akhtar, Ahwaz; Khowaja, Saira N; Khan, Salman; Madhani, Falak; Parekh, Asra; Adnan, Sana; Ahmed, Saman; Chaudhry, Mariam; Hussain, Hamidah; Habib, Ali; Butt, Shahid; Siddiqui, Muhammad R; Ijaz, Raafia; Jamal, Saba; Khan, Abdul B; Keshavjee, Salmaan; Khan, Aamir J; Salahuddin, Naseem; Khan, Palwasha Y
• Is Part Of: Health policy and planning. Volume 37:Issue 8(2022)
• Page Start: 979
• Page End: 989
• Publication Date: 2022-05-09
• Subjects: Tuberculosis -- decentralization -- community -- health outcomes -- lung disease -- developing countries -- geographical information systems -- infectious diseases; Medical policy -- Developing countries -- Periodicals; Public health -- Developing countries -- Periodicals; Health planning -- Developing countries -- Periodicals; 362.1091724
• DOI: 10.1093/heapol/czac038
• Languages: English
• ISSNs: 0268-1080

Abstract

Abstract: Decentralized, person-centred models of care delivery for drug-resistant tuberculosis (DR-TB) continue to be under-resourced in high-burden TB countries. The implementation of such models—made increasingly urgent by the COVID-19 pandemic—are key to addressing gaps in DR-TB care. We abstracted data of rifampicin-resistant (RR)/multidrug-resistant tuberculosis (MDR-TB) patients initiated on treatment at 11 facilities between 2010 and 2017 in Sindh and Balochistan provinces of Pakistan. We analysed trends in treatment outcomes relating to programme expansion to peri-urban and rural areas and estimated driving distance from patient residence to treatment facility. Among the 5586 RR/MDR-TB patients in the analysis, overall treatment success decreased from 82% to 66% between 2010 and 2017, as the programme expanded. The adjusted risk ratio for unfavourable outcomes was 1.013 (95% confidence interval 1.005–1.021) for every 20 km of driving distance. Our analysis suggests that expanding DR-TB care to centralized hubs added to increased unfavourable outcomes for people accessing care in peri-urban and rural districts. We propose that as enrolments increase, expanding DR-TB services close to or within affected communities is essential.