Multiple Coordination‐Derived Bioactive Hydrogel with Proangiogenic Hemostatic Capacity for Wound Repair. Issue 18 (27th July 2022)

• Record Type: Journal Article
• Authors: Luo, Meng; Wang, Yidan; Xie, Chenxi; Lei, Bo
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 18(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-27
• Subjects: bioactive biomaterials -- citrate polymers -- hybrid biomaterials -- multifunctional hydrogels -- wound repair; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202200722
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Bioactive hydrogels with multifunctional properties have shown promising potential in promoting wound repair and skin tissue regeneration. The regulation on different stages of skin wound healing (hemostasis and inflammation) is important for wound repair. Herein, a multiple coordination‐derived bioactive hydrogel (SGPA) with anti‐inflammatory proangiogenic hemostatic capacity for wound repair is reported. The SGPA is prepared through a facile multiple metal coordination action based on the sodium alginate, metal ions (Gd 3+ ), and bisphosphate functionalized polycitrate. The SGPA exhibits a large porous structure, good injectability, and self‐healing performance, as well as controlled biodegradation. Furthermore, the SGPA has good cytocompatibility and hemocompatibility, and can further promote the migration of endothelial cells. The SGPA hydrogel presents good hemostasis capacity in a liver hemorrhage model in vivo. The full‐thickness cutaneous wound model demonstrates that the SGPA hydrogel can effectively accelerate the wound repair through down‐regulating the inflammatory factors and stimulating the angiogenesis around the wound beds. This work suggests that the multiple metal‐organic coordination may be a good strategy to construct the multifunctional bioactive hydrogel for wound repair. Abstract : This work reports a multiple metal‐organic coordination‐derived bioactive hydrogel (SGPA) with anti‐inflammatory proangiogenic hemostatic capacity for wound repair. The SGPA hydrogel can effectively accelerate the wound repair through down‐regulating the inflammatory factors and stimulating the angiogenesis. The multiple metal‐organic coordination may be a good strategy to construct multifunctional bioactive hydrogels for wound repair.