Platelets, mean platelet volume, lymphocytes, leukocytes, and ratios of them altered in patients with hepatitis B virus‐related decompensated cirrhosis. Issue 2 (22nd July 2022)

• Record Type: Journal Article
• Authors: Xu, Changzhi; Yi, Yanhua; Xie, Zhizhi; Zhu, Donglin; Abuduwaili, Dannier; Wang, Zhu; Xi, Yun
• Is Part Of: Precision medical sciences. Volume 11:Issue 2(2022)
• Page Start: 46
• Page End: 50
• Publication Date: 2022-07-22
• Subjects: blood parameters -- decompensated cirrhosis -- hepatitis B virus -- inflammation; Personalized medicine -- Periodicals; Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; 616.994
• DOI: 10.1002/prm2.12070
• Languages: English
• ISSNs: 2642-2514

Abstract

Abstract: Blood routine examination is an inexpensive, routinely performed clinical project, which includes many blood parameters. Hepatitis B virus (HBV) infection may have significant effects on blood parameters in decompensated patients with hepatitis B cirrhosis. However, details were not quite clear yet. A total of 207 HBV‐related decompensated cirrhosis (HBV‐DeCi) patients were included in this retrospective analysis. The included patients were subdivided into three groups: 44 patients with HBsAg, HBeAg, and HbcAb positive were set as Group I; 122 patients with HBsAg, HBeAb, and HbcAb positive were set as Group II; 41 patients with HBsAb, HBeAb, and HbcAb positive were set as Group III. Blood parameters, including platelet (PLT) count, mean platelet volume (MPV), lymphocyte count, leukocyte count and MPV/lymphocyte ratio (MPVLR), lymphocyte/ leukocyte ratio (LLR), platelet/leukocyte ratio (PLR) were analyzed respectively. The correlation between mentioned parameters and the HBV infection were characterized respectively. The values of PLT, MPVLR, and PLR in Group I and II were lower than that in Group III. Group II has a much higher LLR than that in Group I and III. HBV does have significantly effect on blood parameters in HBV‐DeCi patients. Effective treatment must be applied to achieve cirrhosis recompensation promptly. Abstract : Blood parameters and ratios of them had differences among Group I, II, and III. A, PLT comparison among different groups; B, MPVLR comparison among different groups; C, LLR comparison among different groups; D, PLR comparison among different groups. Results showed that PLR, MPVLR, and PLR values of Group I, II, and Group I + II were lower than those of Group III; however, Group II had significantly higher LLR compared to Group III.