IDDF2022-ABS-0250 Assessment of prevalence and predictors of micronutrient deficiency in patients with ulcerative colitis and relationship with quality of life. (2nd September 2022)

• Record Type: Journal Article
• Authors: Sachan, Anurag; Dutta, Usha; Sharma, Vishal; Samanta, Jayanta; Bhadada, Sanjay; Sharma, Arun; Prasad, Kaushal
• Is Part Of: Gut. Volume 71(2022)Supplement 2
• Page Start: A170
• Page End: A171
• Publication Date: 2022-09-02
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2022-IDDF.239
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: To study the prevalence and predictors of nutritional deficiencies and poor quality of life (QOL) in patients with Ulcerative colitis (UC). Methods: It was a cross-sectional prospective study done on patients with UC over one year. Relevant clinical, anthropometric, and laboratory investigation data were collected. Patients with significant comorbid conditions were excluded. Cases were defined as patients with UC and controls were healthy relatives of the cases. Short inflammatory bowel disease questionnaire (SIBDQ) score <50 denoted poor QOL. Results: 126 patients with UC and well-matched 57 healthy controls were analyzed. Patients with UC as compared to controls had increased prevalence of being underweight (27.8%v/s3.50%), low mid-arm-circumference (45.23%v/s12.28%), weak handgrip strength (66.66%v/s45.61%) and weak lower limb strength (80.15%v/s42.10%). Patients with UC showed higher protein deficiency (30.95%v/s3.50%), albumin-deficiency (25.39%v/s0%) and cholesterol-deficiency (62.69%v/s28.07%). Micronutrient deficiency was also significantly more prevalent in patients: calcium-deficiency (44.44%v/s5.26%) and phosphate-deficiency (20.63%v/s1.75%). Other micronutrient deficiencies had increased prevalence in patients – Iron-deficiency (87.3%), Folate-deficiency (15.9%), Vitamin B12 deficiency (10.3%) and vitamin D-deficiency(<11ng/ml) (19.8%). Serum albumin and iron deficiency emerged as independent predictors of serum calcium-deficiency with OR of 6.8 and 13.4 respectively. Serum folate-deficiency emerged as an independent predictor of magnesium-deficiency with OR of 3.93. Serum calcium emerged as an independent predictor of serum iron-deficiency with OR of 11.56. Serum albumin-deficiency emerged as an independent predictor of vitamin D-deficiency with OR of 4.43. 85 (67.46%) of patients had poor QOL. Vitamin D (r=0.275), and albumin levels (r=0.399) positively correlated with quality of life. Vitamin D-insufficiency(<32ng/ml) and histologically active disease by Robarts score >3 emerged as independent predictors of poor quality of life with OR of 6.0 and 4.0 respectively. Conclusions: Micro and macro-nutrient deficiencies are more prevalent in patients with UC than in healthy controls. Albumin levels correlated well with micronutrient deficiencies and QOL. Vitamin D-insufficiency and histologically active disease predict the poor QOL.