IDDF2022-ABS-0168 Global incidence of oesophageal cancer by histological subtypes in 2020: a systematic analysis of registries. (2nd September 2022)

• Record Type: Journal Article
• Authors: Huang, Junjie; Lok, Veeleah; Zhang, Lin; Lucero-Prisno, Don Eliseo; Xu, Wanghong; Zheng, Zhi-Jie; Elcarte, Edmar; Withers, Mellissa; Wong, Martin
• Is Part Of: Gut. Volume 71(2022)Supplement 2
• Page Start: A152
• Page End: A152
• Publication Date: 2022-09-02
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2022-IDDF.211
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Background: Oesophageal cancer is one of the most common cancers and a leading cause of cancer death. It has an aggressive disease nature and poor survival rate, resulting in a substantial cancer burden globally. We aimed to investigate the most updated global incidence of oesophageal cancer by histological subtypes using international and national cancer registries. Methods: The data on the incidence of oesophageal cancer by histological subtypes in 2020 were calculated based on WHO Cancer Incidence in Five Continents and Global Cancer Observatory. Age-standardised rates for oesophageal cancer incidence by histological subtypes were adjusted by the world standard population. Results: In 2020, the global oesophageal cancer incidence was estimated to be 6.3 per 100 000 persons with 604100 cases. The global squamous cell carcinoma incidence was 5.3, with higher incidence observed in the male population (7.7 vs. 3.2 in females); Eastern Asia (11.2), South Central Asia (5.2), Sub-Saharan Africa (3.9), and Central and Eastern Europe (2.4); and countries with high HDI (8.1 vs. 2.2 for very high HDI countries). The global oesophageal adenocarcinoma incidence was 0.95, with higher incidence observed in the male population (1.5 vs. 0.40 in females); Northern Europe (3.3), Northern America (1.9), Oceania (1.8), and Western Europe (1.8); and countries with very high HDI (1.3 vs. 0.48 for medium HDI countries). Conclusions: Squamous cell carcinoma remains the predominant subtype of oesophageal cancer, especially in Eastern Asia, South Central Asia, and Sub-Saharan Africa. The oesophageal adenocarcinoma incidence was the highest in Northern Europe, Northern America, and Oceania. Further studies are needed to explore the reasons for the disparities in oesophageal cancer distribution by histological subtypes