Ultra‐Bright Near‐Infrared Sulfonate‐Indolizine Cyanine‐ and Squaraine‐Albumin Chaperones: Record Quantum Yields and Applications. Issue 9 (15th September 2022)

• Record Type: Journal Article
• Authors: Meador, William E.; Kapusta, Karina; Owolabi, Iyanuoluwani; Autry, Shane A.; Saloni, Julia; Kolodziejczyk, Wojciech; Hammer, Nathan I.; Flynt, Alex S.; Hill, Glake A.; Delcamp, Jared H.
• Is Part Of: ChemPhotoChem. Volume 6:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-15
• Subjects: Photochemistry -- Periodicals; Periodicals; Electronic journals; 541.35
• DOI: 10.1002/cptc.202200237
• Languages: English
• ISSNs: 2367-0932

Abstract

Abstract: The Front Cover shows a single near‐infrared dye being laser‐excited and dimly fluorescing in an aqueous biological environment compared to a near‐infrared dye bound to albumin fluorescing brightly in the same environment. Cover designed by Karina Kapusta. Read the full text of the Research Article at 10.1002/cptc.202200127 . Abstract : "This research report shows how dyes can be rationally designed to give ultrabright emission in the near‐infrared spectral region by tightly binding to albumin. Two applications are demonstrated with record setting detectivity for albumin, and the imaging of α‐tubulin via immunohistochemistry with a biotinylated albumin–dye chaperone. The cover picture depicts the difference in brightness if the dye is free or bound to albumin, and the cover profile discusses how the project was conceived and exciting next steps for this research direction.…" This and more about the story behind the front cover can be found in the Research Article at 10.1002/cptc.202200127 .