Heart rate variability during head‐up tilt shows inter‐individual differences among healthy individuals of extreme Prakriti types. Issue 17 (15th September 2022)

• Record Type: Journal Article
• Authors: Rani, Ritu; Rengarajan, Prathiban; Sethi, Tavpritesh; Khuntia, Bharat Krushna; Kumar, Arvind; Punera, Deep Shikha; Singh, Deepika; Girase, Bhushan; Shrivastava, Ankita; Juvekar, Sanjay K.; Pesala, Bala; Mukerji, Mitali; Deepak, Kishore Kumar; Prasher, Bhavana
• Is Part Of: Physiological reports. Volume 10:Issue 17(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-15
• Subjects: autonomic nervous system -- Ayurgenomics -- Ayurveda -- head‐up tilt -- heart rate variability -- orthostatic stress -- Prakriti; Physiology -- Periodicals; 571
• DOI: 10.14814/phy2.15435
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: Autonomic modulation is critical during various physiological activities, including orthostatic stimuli and primarily evaluated by heart rate variability (HRV). Orthostatic stress affects people differently suggesting the possibility of identification of predisposed groups to autonomic dysfunction‐related disorders in a healthy state. One way to understand this kind of variability is by using Ayurvedic approach that classifies healthy individuals into Prakriti types based on clinical phenotypes. To this end, we explored the differential response to orthostatic stress in different Prakriti types using HRV. HRV was measured in 379 subjects( Vata = 97, Pitta = 68, Kapha = 68, and Mixed Prakriti = 146) from two geographical regions(Vadu and Delhi NCR) for 5 min supine (baseline), 3 min head‐up‐tilt (HUT) at 60°, and 5 min resupine. We observed that Kapha group had lower baseline HRV than other two groups, although not statistically significant. The relative change (% Δ 1&2 ) in various HRV parameters in response to HUT was although minimal in Kapha group. Kapha also had significantly lower change in HR, LF (nu), HF (nu), and LF/HF than Pitta in response to HUT. The relative change (% Δ 1 ) in HR and parasympathetic parameters (RMSSD, HF, SD1) was significantly greater in the Vata than in the Kapha . Thus, the low baseline and lower response to HUT in Kapha and the maximum drop in parasympathetic activity of Vata may indicate a predisposition to early autonomic dysfunction and associated conditions. It emphasizes the critical role of Prakriti ‐based phenotyping in stratifying the differential responses of cardiac autonomic modulation in various postures among healthy individuals across different populations. Abstract : Differential response to Orthostatic stress among Prakriti groups : Healthy individuals stratified into Ayurveda Prakriti groups, subjected to orthostatic stress (head up tilt), and had heart rate (HR) and heart rate variability measured (upper panel). Lower panel a and b depict the response ( Δ 1 & 2) to orthostatic stress. Each color line represents Prakriti groups in the order corresponding to the magnitude of change observed. Response was seen greater in the Vata group in HR and parasympathetic parameters. Whereas Kapha Prakriti individuals were least responsive in HUT.