Front Cover Picture: Expanding the Scope of Enantioselective Halohydrin Dehalogenases – Group B (Adv. Synth. Catal. 15/2022). Issue 15 (14th July 2022)

• Record Type: Journal Article
• Authors: Mehić, Emina; Hok, Lucija; Wang, Qian; Dokli, Irena; Miklenić, Marina Svetec; Blažević, Zvjezdana Findrik; Tang, Lixia; Vianello, Robert; Elenkov, Maja Majerić
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 15(2022)
• Page Start: 2461
• Page End: 2461
• Publication Date: 2022-07-14
• Subjects: biocatalysis -- halohydrin dehalogenase -- epoxides -- kinetic resolution -- molecular modelling; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202200715
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract : The front cover picture was designed by Emina Mehić and Lucija Hok, and illustrated by Josipa Zeba. (© Josipa Zeba. Reproduced with permission.) It depicts the halohydrin dehalogenase‐catalysed conversion of epoxides. Extensive screening of enzymes from group B revealed several highly enantioselective transformations, with HheB showing higher enantioselectivity and activity toward a larger panel of substrates compared to HheB2. By using site‐directed mutagenesis, residues 120 and 125 were found to be responsible for higher enantioselectivity of HheB compared to HheB2. Due to remarkable activity and enantioselectivity, B‐group HHDHs emerged as a catalyst of choice for the synthesis of bulky tertiary alcohols. Details can be found in the Research Article by Majerić Elenkov, Vianello and co‐workers (E. Mehić, L. Hok, Q. Wang, I. Dokli, M. Svetec Miklenić, Z. Findrik Blažević, L. Tang, R. Vianello, M. Majerić Elenkov, Adv. Synth. Catal . 2022, 364, 2576–2588; DOI: 10.1002/adsc.202200342 ).