Dynamics of the Immune Response in Hospitalized SARS-CoV-2-infected Cancer Patients. (21st October 2022)

• Record Type: Journal Article
• Authors: Aoki, Mateus Nóbrega; Nardin, Jeanine Marie; Huergo, Luciano Fernandes; Blanes, Lucas; Morales, Hugo Manuel Paz; Fornazari, Bruna; Conzentino, Marcelo Santos; Migliorini, Maria Eduarda Alencar; Zanette, Dalila Lucíola
• Is Part Of: Cancer investigation. Volume 40:Number 9(2022)
• Page Start: 750
• Page End: 759
• Publication Date: 2022-10-21
• Subjects: COVID-19 -- IgG antibodies -- cancer -- seroconversion -- immunity; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2112693
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Seroconversion rates were compared between oncological and nononcological patients infected with SARS-CoV-2 during a 14-day hospitalization time. All COVID-19 non-oncological and solid malignancies patients reached 100% seroconversion at day 14, while less than half of the hematological patients were seroconverted at the same time point. Despite the limited number and variability of the patient's cohort, we conclude that there is a delayed seroconversion in the hematological malignancies group, which may be linked to changes in the hematological parameters, immune suppression and/or oncological treatments that are typically associated with these patients.