The prognostic impact of ABO blood type in pancreatic cancer: Relevance to adjuvant chemotherapy. (10th May 2022)

• Record Type: Journal Article
• Authors: Tezuka, Koji; Ohgi, Katsuhisa; Okamura, Yukiyasu; Sugiura, Teiichi; Ito, Takaaki; Yamamoto, Yusuke; Ashida, Ryo; Otsuka, Shimpei; Todaka, Akiko; Uesaka, Katsuhiko
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 29:Number 8(2022)
• Page Start: 922
• Page End: 931
• Publication Date: 2022-05-10
• Subjects: blood antigen -- pancreatic ductal adenocarcinoma -- precision medicine -- recurrence pattern -- survival; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.1152
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background/Purpose: The aim of this study was to investigate the prognostic impact of ABO blood type in resected pancreatic cancer (PC), with a focus on adjuvant chemotherapy. Methods: We retrospectively analyzed 510 patients who underwent pancreatectomy for PC between 2006 and 2017. Survival outcomes were investigated according to blood type and adjuvant chemotherapy regimen (S‐1, gemcitabine, or no adjuvant chemotherapy). Results: Among the 510 patients, the overall survival (OS) of patients with blood type O was significantly better compared to those with blood type non‐O (5‐year OS rate, 46.6% vs 30.5%, P = .025). In 241 patients treated with adjuvant S‐1, the 5‐year OS of patients with blood type O was significantly better than those with blood type non‐O (70.7% vs 44.2%, P = .001). Multivariate analysis showed that blood type non‐O was an independent prognostic factor for OS in the overall cohort (hazard ratio [HR]: 1.58, P = .002) and in patients treated with adjuvant S‐1 (HR: 2.99, P < .001). In patients treated with adjuvant gemcitabine or no adjuvant chemotherapy, there was no significant difference in OS between patients with blood type O and those with blood type non‐O. Conclusions: Blood type O predicted favorable survival in patients with resected PC, which was associated with adjuvant S‐1. Abstract : Tezuka et al revealed that blood type O was an independent favorable prognostic factor for overall survival in patients with resected pancreatic cancer treated with adjuvant S‐1. The ABO blood type is a potential and readily available predictive biomarker of benefit from adjuvant treatment with S‐1 in pancreatic cancer.