Iron(iii)-catalyzed α-cyanation and carbonylation with 2-pyridylacetonitrile: divergent synthesis of α-amino nitriles and tetrahydroisoquinolinones. Issue 35 (26th August 2022)

• Record Type: Journal Article
• Authors: Xu, Fan; Zhang, Fanglian; Wang, Wenjia; Yao, Mingxu; Lin, Xing; Yang, Fang; Qian, Yiping; Chen, Zhengwang
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 35(2022)
• Page Start: 7031
• Page End: 7035
• Publication Date: 2022-08-26
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01199a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient iron-catalyzed divergent synthesis of α-amino nitriles and tetrahydroisoquinolinones under an oxygen atmosphere. Abstract : Iron-catalyzed oxidative synthesis of N -aryl-substituted tetrahydroisoquinolines (THIQs) toward tetrahydroisoquinoline-based derivatives is reported. A wide range of α-amino nitriles and tetrahydroisoquinolinones are synthesized in moderate to good yields. This approach involves a new organic nitrile source, a cheap iron catalyst under an oxygen atmosphere, and temperature-controlled divergent synthesis and features complete selectivity and operational simplicity.