Management of fluorescent organic/inorganic nanohybrids for biomedical applications in the NIR-II region. (21st July 2022)

• Record Type: Journal Article
• Authors: Li, Benhao; Zhao, Mengyao; Lin, Jing; Huang, Peng; Chen, Xiaoyuan
• Is Part Of: Chemical Society reviews. Volume 51:Number 18(2022)
• Page Start: 7692
• Page End: 7714
• Publication Date: 2022-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cs00131d
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : This paper reviews organic and inorganic species as building blocks and various design strategies of NIR-II nanohybrids for intensity-based and lifetime-based bioimaging and biosensing. Abstract : Biomedical fluorescence imaging in the second near-infrared (NIR-II, 100–1700 nm) window provides great potential for visualizing physiological and pathological processes, owing to the reduced tissue absorption, scattering, and autofluorescence. Various types of NIR-II probes have been reported in the past decade. Among them, NIR-II organic/inorganic nanohybrids have attracted widespread attention due to their unique properties by integrating the advantages of both organic and inorganic species. Versatile organic/inorganic nanohybrids provide the possibility of realizing a combination of functions, controllable size, and multiple optical features. This tutorial review summarizes the reported organic and inorganic species in nanohybrids, and their biomedical applications in NIR-II fluorescence and lifetime imaging. Finally, the challenges and outlook of organic/inorganic nanohybrids in biomedical applications are discussed.