Management of acute sickle cell priapism in an African (Togo) pediatric department includes conservative measures and intracavernous epinephrine which is safe and efficacious. Issue 3 (26th April 2022)

• Record Type: Journal Article
• Authors: Guedenon, Koffi Mawuse; Fiawoo, Mawouto; Akolly, Djatougbe Ayaovi Elie; Akpako, Etse; Esso, Balakibawi; Dossou, Fidèle Comlan; Gbadoe, Adama Dodji
• Is Part Of: EJHaem. Volume 3:Issue 3(2022)
• Page Start: 628
• Page End: 635
• Publication Date: 2022-04-26
• Subjects: epinephrine -- priapism -- sickle cell (patient); Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.440
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: Priapism is a well‐known urologic complication of sickle cell anemia. This study describes the results of a protocol for the treatment of acute priapism by intracavernous injection of epinephrine due to unavailability of etilefrine. A descriptive cross‐sectional study of 18 cases of acute priapism in sickle cell patients treated in the pediatric department of the Sylvanus Olympio CHU from January 1 to December 31, 2020. The average age was 21.7 ± 7.7 years, the youngest patient was 8 and the oldest was 32 years old. Students represented 61.1% of the patients. The hemoglobin profiles were homozygous SS ( n = 14) and double heterozygous SC ( n = 4). Most of the crisis (83.3%) occurred at night. Most of the patients (66.7%) came to the hospital before the sixth hour of crisis, one patient came by the 48th hour. Walking was the most self‐relief method tried by patients (67%). It was followed by a cold penile bath, attempted urination, body bath, and lastly lukewarm bath. Fourteen patients had a history of chronic intermittent priapism. The average pain intensity was 9.5 ± 0.9 with restlessness (33.3%) and crying (33.3%). Fifteen patients were treated upon admission with an intracavernosal injection of epinephrine, and three patients were first drained. Thirteen patients achieved remission immediately, while five patients required a second injection and only one had to be drained before remission. Tolerance was good. One patient had a borderline systolic blood pressure. One erectile weakness case was noticed and no cases of sexual impotence. Epinephrine by intracavernosal injection is an efficient treatment for acute priapism in sickle cell patients. Epinephrine, which has a good tolerance in pediatric and young adult patients, should be used in lieu of etilefrine due to its unavailability in areas where it is unavailable.