A novel furo[3, 2-c]pyridine-based AIE photosensitizer for specific imaging and photodynamic ablation of Gram-positive bacteria. Issue 74 (30th August 2022)

• Record Type: Journal Article
• Authors: Wu, Ming-Yu; Wang, Yun; Wang, Li-Juan; Wang, Jia-Li; Xia, Feng-Wei; Feng, Shun
• Is Part Of: Chemical communications. Volume 58:Issue 74(2022)
• Page Start: 10392
• Page End: 10395
• Publication Date: 2022-08-30
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc04084k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel AIE-active furo[2, 3- c ]pyridine-based photosensitizer was developed for specific imaging and photodynamic ablation of Gram-positive bacteria in vitro and in vivo . Abstract : An Rh-catalyzed tandem reaction was performed to construct an AIE-active furo[2, 3- c ]pyridine-based photosensitizer, named LIQ-TF . LIQ-TF showed near-infrared emission with high quantum yield, and high 1 O2 and ˙OH generation efficiency, and could be used for specific imaging and photodynamic ablation of Gram-positive bacteria in vitro and in vivo, showing great potential for combating multiple drug-resistant bacteria.