Facile synthesis of silver decorated biochar as a novel and highly active biosourced anti-kinetoplastid agent. (August 2022)

• Record Type: Journal Article
• Authors: Snoussi, Youssef; Sifaoui, Inès; Khalil, Ahmed M.; Bhakta, Arvind K.; Semyonov, Oleg; Postnikov, Pavel S.; Michely, Laurent; Pires, Rémy; Bastide, Stéphane; Barroso, José Enrique-Piñero; Morales, Jacob Lorenzo; Chehimi, Mohamed M.
• Is Part Of: Materials today communications. Volume 32(2022)
• Publication Date: 2022-08
• Subjects: Leishmania -- Neglected tropical diseases -- Antiparasitic nanocomposite -- Agrowaste -- Olive pit -- Biochar -- Silver nanoparticles -- Trash to treasure; Materials science -- Periodicals; 620.11
• DOI: 10.1016/j.mtcomm.2022.104126
• Languages: English
• ISSNs: 2352-4928

Abstract

Abstract: Neglected tropical diseases include Chagas disease, also known as American Trypanosomiasis and leishmaniasis remain a serious health problem in several endemic. To address this medical problem, much has been done in the past 15 years, to design nanomaterials with effective anti-kinetoplastid activity, particularly those nanomaterials based on gold and silver nanoparticles. Herein, we describe a simple method to prepare silver-loaded biochar by pyrolysis of silver nitrate-impregnated agrowaste powder (from olive stones). The resulting Biochar@Ag was prepared at 400 °C for 15 min, and the yield was found to be 36.5 %. The supported metallic Ag nanoparticles have triangular shape in the nanoscale regime (< 100 nm) and a loading of 7.85 mmol per gram of Biochar@Ag. The Biochar@Ag showed highly promising antiparasitic activity against promastigotes stage of L. donovani, L. amazonensis and epimastigotes of T. cruzi with an IC50 of 9.942 ± 0.900 ppm; 14.555 ± 1.035 ppm and 12.154 ± 0.206 ppm, respectively. From the above, this work conclusively demonstrates that slow pyrolysis is a unique thermochemical approach to valorize agrowastes into highly effective anti-kinetoplastid silver-loaded biochar with remarkably low cytotoxicity towards murine macrophages. Graphical Abstract: ga1 Highlights: Olive pit-derived biochar bearing silver nanoparticles has been prepared by one step slow pyrolysis. Silver nanoparticles are densely and evenly dispersed over biochar particles. Silver-loaded biochar has antiparasitic activity against L. donovani, L. amazonensis and T. cruzi . Waste and junk conversion to bioactive nanocomposites opens new horizons in treating neglected tropical diseases.