A nanoplatform for mild-temperature photothermal and type I & II photodynamic therapy in the NIR-II biowindow. Issue 74 (25th August 2022)

• Record Type: Journal Article
• Authors: Lu, Bing; Zhang, Zhecheng; Huang, Yuying; Zhang, Yuehua; Wang, Jin; Ding, Yue; Wang, Yang; Yao, Yong
• Is Part Of: Chemical communications. Volume 58:Issue 74(2022)
• Page Start: 10353
• Page End: 10356
• Publication Date: 2022-08-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc03248a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new strategy for tumor phototherapy based on the combination of mild-temperature photothermal therapy and type I & II photodynamic therapy. Abstract : In the current work, we synthesized an A–D–A smallmolecule photosensitizer, denoted as DPTTIC, and a dual PEG-functionalized pillararene, denoted as WP5-8C-2PEG, and used them to construct novel DPTTIC nanoparticles (NPs) displaying NIR II absorption. Under 980 nm-wavelength laser irradiation, DPTTIC NPs performed well in mild-temperature photothermal and type I & II photodynamic anti-tumor therapy.