Construction of an inter-organ transomic network for whole-body metabolism. (August 2022)

• Record Type: Journal Article
• Authors: Kokaji, Toshiya; Kuroda, Shinya
• Is Part Of: Current opinion in endocrine and metabolic research. Volume 25(2022)
• Publication Date: 2022-08
• Subjects: Transomic analysis -- Multiomic analysis -- Network -- Metabolism -- Inter-organ -- Intra-organ; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrine System Diseases; Metabolic Diseases; Endocrine glands -- Diseases; Metabolism -- Disorders; Periodical; Electronic journals; Periodicals; Electronic journals; 616.4
• DOI: 10.1016/j.coemr.2022.100361
• Languages: English
• ISSNs: 2451-9650

Abstract

Abstract: Systemic metabolism is regulated by inter-organ communication at the whole-body level, and at the intra-organ level, there are also numerous factors involved in metabolic regulation. Transomic analysis is used to construct a metabolic regulatory network by integrating multiple factors obtained by multiomic analysis with interaction information. This review provides an overview of multiomic technologies and databases for intra- and inter-organ interactions, and discusses methods for constructing inter-organ transomic networks and their applications. Highlights: Transomic analysis is a methodology for network construction using multiomic dataset. Intra-organ transomic network can identify pathological pathways of metabolic disease. Intra-organ networks can be connected by adding omic datasets of blood compartment. Inter-organ network can give insights into whole-body metabolic abnormalities.