In-water synthesis of isocyanides under micellar conditions. Issue 18 (30th August 2022)

• Record Type: Journal Article
• Authors: Brunelli, Francesca; Aprile, Silvio; Russo, Camilla; Giustiniano, Mariateresa; Tron, Gian Cesare
• Is Part Of: Green chemistry. Volume 24:Issue 18(2022)
• Page Start: 7022
• Page End: 7028
• Publication Date: 2022-08-30
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d2gc01398c
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Dehydration of N -formamides to isocyanides using p -toluen sulphonyl chloride, sodium hydrogen carbonate in aqueous micelles is reported. Abstract : An in-water dehydration of N -formamides to afford isocyanides using micellar conditions at room temperature is reported. This method allows for the preparation of aliphatic isocyanides in an environmental friendly manner. The replacement of undesirable components such as phosphorous oxychloride, triethyl amine and dichloromethane (the classical combination used for the dehydration of N -formamides), by p -toluen sulphonyl chloride, sodium hydrogen carbonate and water makes this transformation really sustainable and safe.