Impact of SARS‐CoV2 on youth onset type 2 diabetes new diagnoses and severity. Issue 8 (20th August 2022)

• Record Type: Journal Article
• Authors: DeLacey, Sean; Arzu, Jennifer; Levin, Laura; Ranganna, Adesh; Swamy, Anita; Bianco, Monica E.
• Is Part Of: Journal of diabetes. Volume 14:Issue 8(2022)
• Page Start: 532
• Page End: 540
• Publication Date: 2022-08-20
• Subjects: COVID‐19 -- pandemic -- pediatric -- type 2 diabetes; 新型冠状病毒肺炎 -- 2型糖尿病 -- 儿科 -- 大流行; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.13301
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Introduction: Initial reports show an increase in youth onset type 2 diabetes during the COVID‐19 pandemic. We aim to expand on existing evidence by analyzing trends over a longer period. Objectives: Our study aims to describe change in the amount, severity, and demographics of youth onset type 2 diabetes diagnoses during the COVID‐19 pandemic compared to the five years before. Methods: We performed a retrospective cross‐sectional review of youth (age ≤ 21) diagnosed with type 2 diabetes during the COVID‐19 pandemic (1 May 2020–30 April 2021) and the five years before (1 May 2015–30 April 2020) at a tertiary care center. Children were identified by International Classification of Diseases codes. Charts were reviewed to confirm diagnosis. Chi‐square, t tests, and Fisher's exact tests were used for analyses. Results: In the prepandemic era annual diagnoses of type 2 diabetes ranged from 41–69 (mean = 54.2), whereas during the pandemic period 159 children were diagnosed, an increase of 293%. The increase resulted in a higher incidence rate ratio during the pandemic than before, 2.77 versus 1.07 ( p = .006). New diagnoses increased most, by 490%, in Non‐Hispanic Black patients. The average HbA1c at presentation was higher during the pandemic (9.5% ± 2.6) (79.9 mmol/mol ± 28.2) than before (8.7%±2.1) (72.1 mmol/mol ± 23.1) ( p = .003). Of those diagnosed during the pandemic, 59% were tested for COVID‐19 and three tested positive. Conclusions: New diagnoses of type 2 diabetes increased during the pandemic, most notably in Non‐Hispanic Black youth. There was not a significant correlation found with clinical or biochemical COVID‐19 infection in those tested. Abstract : Highlights There has been an increase in new cases of youth onset type 2 diabetes during the pandemic. Non‐Hispanic Black youth have been most affected the increase in youth onset type 2 diabetes during the pandemic. No significant correlation was identified with clinical or biochemical COVID‐19 infection in those tested. 摘要: 背景: 初步报告显示, 在新型冠状病毒肺炎大流行期间, 青年发病的2型糖尿病患者有所增加。我们的目标是通过分析更长时期的趋势来扩大现有证据。 方法: 我们对在新型冠状病毒肺炎大流行期间(2020年5月1日至2021年4月30日)和之前五年(2015年5月1日至2020年4月30日)在三级护理中心被诊断为2型糖尿病的年轻人(年龄≤21岁)进行了横向回顾。儿童通过ICD(国际疾病分类)代码进行识别。通过图表以确认诊断。分析方式采用了卡方检验, t检验和Fisher's精确检验。 结果: 在大流行前, 2型糖尿病的年诊断率为41‐69例(平均为54.2例), 而在大流行期间, 有159名儿童确诊, 增加了293%。这一增加导致大流行期间的发病率比以前更高, 分别为2.77vs1.07(p=0.006)。在非西班牙裔黑人患者中, 新诊断增加最多, 增长了490%。发病时HbA1c平均值(9.5%±2.6)(79.9mmol/mol ± 28.2)高于发病前(8.7%±2.1)(72.1mmol/mol ± 23.1)(p=0.003)。在疫情期间确诊的患者中, 59%的人进行了新型冠状病毒肺炎检测, 3人检测呈阳性。 结论: 在大流行期间, 新诊断的2型糖尿病增加。最显著的是在非西班牙裔黑人青年中。在接受测试的人中, 没有发现与临床或生化指标与新型冠状病毒肺炎感染有显著相关性。