Catalyst-free highly regioselective hydrated ring-opening and formylation of quinazolinones. Issue 33 (8th August 2022)

• Record Type: Journal Article
• Authors: Yu, Xianglin; Tang, Zhiliang; He, Kun; Li, Weina; Lin, Jun; Jin, Yi
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 33(2022)
• Page Start: 6654
• Page End: 6658
• Publication Date: 2022-08-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01234k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A catalyst-free method for the highly regioselective hydrated ring-opening and formylation of quinazolinones was developed. Abstract : A catalyst-free method for the highly regioselective hydrated ring-opening and formylation of quinazolinones was developed. This reaction realized the direct arylation of two nitrogen atoms on quinazolinones and realized the regioselective ring-opening of quinazolinone and subsequent acylation of methyleneamine through the nucleophilic addition of a water molecule to an imine carbon atom. It showed reasonable functional group compatibility and provided one-pot access to a variety of N -arylformyl derivatives in moderate to excellent yields.