Hollow protein microparticles formed through cross-linking by an Au3+ initiated redox reaction. Issue 33 (14th June 2022)

• Record Type: Journal Article
• Authors: Schijven, Laura M. I.; Vogelaar, Thomas D.; Sridharan, Simha; Saggiomo, Vittorio; Velders, Aldrik H.; Bitter, Johannes H.; Nikiforidis, Constantinos V.
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 33(2022)
• Page Start: 6287
• Page End: 6295
• Publication Date: 2022-06-14
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb00823h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : We report the formation of hollow microparticles through the assembly of lipoproteins in CaCO3 templates and cross-linking by using Au 3+ ions. Abstract : Hollow microparticles (MPs) are of great relevance in the materials industry for a wide range of applications, such as catalysis, coatings, and delivery of theranostics. Here, we report the formation of hollow MPs through the assembly of lipoproteins in CaCO3 templates. Proteins interact in the pores of CaCO3 templates through attractive hydrophobic forces and form dense edges of hollow MPs. To further cross-link the proteins, Au 3+ was added to initiate a redox reaction, where proteins were oxidized forming inter- and intramolecular covalent bonds, while Au 3+ was reduced and gold nanoparticles (AuNPs) were formed. The obtained protein-based hollow MPs have a diameter of 6 μm and the AuNPs are embedded on their surface. Through this research, we suggest a new route to design biobased Au-protein hollow MPs in simple steps, which can allow new possibilities for carrying functional molecules and bioimaging.