Posttreatment Gene Scores Support Histologic and Endoscopic Response Thresholds in Eosinophilic Esophagitis. (26th September 2022)

• Record Type: Journal Article
• Authors: Ruffner, Melanie A.; Cotton, Cary C.; Dellon, Evan S.
• Is Part Of: American journal of gastroenterology. Volume 117:Number 9(2022)
• Page Start: 1519
• Page End: 1522
• Publication Date: 2022-09-26
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001802
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: The correlation between clinical and molecular treatment response thresholds in eosinophilic esophagitis (EoE) is not well understood. METHODS: We evaluated posttreatment EoE diagnostic panel gene expression profiles across histologic and endoscopic thresholds (EREFS) in a prospective adult EoE cohort. RESULTS: We observed a strong inverse correlation between posttreatment gene score and eosinophil count (R = −0.66; P < 0.001); biopsies with <15 eos/hpf had higher gene scores (≥425) vs those with ≥15 eos/hpf. Findings for EREFS were similar; EREFS ≤2 was associated with EoE diagnostic panel scores ≥395. DISCUSSION: Molecular signatures support the use of posttreatment response thresholds <15 eos/hpf and EREFS ≤2 in clinical practice and trials.