Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis. Issue 6 (June 1995) - Bruyn, R P
Abstract : Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.