Effect of metoclopramide on transport in the small intestine of the dog. Issue 12 (December 1969)

• Record Type: Journal Article
• Authors: Tinker, John; Cox, Alan G.
• Is Part Of: Gut. Volume 10:Issue 12(1969)
• Page Start: 986
• Page End: 989
• Publication Date: 1969-12
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.10.12.986
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : A method is described for the simultaneous measurement of flow rate, mean transit time, and volume of the intestine during the transport of fluid through a segment of the small intestine of the dog. Using this method, the effect of metoclopramide on motility of the small bowel was assessed. The drug resulted in a decrease in transit time and volume in the test segment of bowel while the flow rate remained constant. This finding suggests that metoclopramide-stimulated contraction of intestinal smooth muscle.