Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Issue 11 (26th April 2017)

• Record Type: Journal Article
• Authors: Faust, Hilary E; Golden, Jeffrey A; Rajalingam, Raja; Wang, Angelia S; Green, Gary; Hays, Steven R; Kukreja, Jasleen; Singer, Jonathan P; Wolters, Paul J; Greenland, John R
• Is Part Of: Thorax. Volume 72:Issue 11(2017)
• Page Start: 1052
• Page End: 1054
• Publication Date: 2017-04-26
• Subjects: Lung Transplantation; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2016-209897
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Telomere length (TL) decreases with cellular ageing and biological stressors. As advanced donor and recipient ages are risk factors for chronic lung allograft dysfunction (CLAD), we hypothesised that decreased age-adjusted donor TL would predict earlier onset of CLAD. Shorter donor TL was associated with increased risk of CLAD or death (HR 1.26 per 1 kb TL decrease, 95% CI 1.03 to 1.54), particularly for young donors. Recipient TL was associated with cytopenias but not CLAD. Shorter TL was also seen in airway epithelium for subjects progressing to CLAD (p=0.02). Allograft TL may contribute to CLAD pathogenesis and facilitate risk stratification.