Association between right ventricular strain and outcomes in patients with dilated cardiomyopathy. Issue 15 (2nd November 2020)

• Record Type: Journal Article
• Authors: Liu, Tong; Gao, Yifeng; Wang, Hui; Zhou, Zhen; Wang, Rui; Chang, San-Shuai; Liu, Yuanyuan; Sun, Yuqing; Rui, Hongliang; Yang, Guang; Firmin, David; Dong, Jianzeng; Xu, Lei
• Is Part Of: Heart. Volume 107:Issue 15(2021)
• Page Start: 1233
• Page End: 1239
• Publication Date: 2020-11-02
• Subjects: cardiac imaging and diagnostics -- advanced cardiac imaging -- cardiac magnetic resonance (CMR) imaging -- heart failure -- myocardial disease; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2020-317949
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To explore the association between three-dimensional (3D) cardiac magnetic resonance (CMR) feature tracking (FT) right ventricular peak global longitudinal strain (RVpGLS) and major adverse cardiovascular events (MACEs) in patients with stage C or D heart failure (HF) with non-ischaemic dilated cardiomyopathy (NIDCM) but without atrial fibrillation (AF). Methods: Patients with dilated cardiomyopathy were enrolled in this prospective cohort study. Comprehensive clinical and biochemical analysis and CMR imaging were performed. All patients were followed up for MACEs. Results: A total of 192 patients (age 53±14 years) were eligible for this study. A combination of cardiovascular death and cardiac transplantation occurred in 18 subjects during the median follow-up of 567 (311, 920) days. Brain natriuretic peptide, creatinine, left ventricular (LV) end-diastolic volume, LV end-systolic volume, right ventricular (RV) end-diastolic volume and RVpGLS from CMR were associated with the outcomes. The multivariate Cox regression model adjusting for traditional risk factors and CMR variables detected a significant association between RVpGLS and MACEs in patients with stage C or D HF with NIDCM without AF. Kaplan-Meier analysis based on RVpGLS cut-off value revealed that patients with RVpGLS <−8.5% showed more favourable clinical outcomes than those with RVpGLS ≥−8.5% (p=0.0037). Subanalysis found that this association remained unchanged. Conclusions: RVpGLS-derived from 3D CMR FT is associated with a significant prognostic impact in patients with NIDCM with stage C or D HF and without AF.