Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke. Issue 4 (3rd December 2009)

• Record Type: Journal Article
• Authors: Fridman, Esteban A; Crespo, Marcos; Gomez Argüello, Santiago; Degue, Lorena; Villarreal, Mirta; Bohlhalter, Stephan; Wheaton, Lewis; Hallett, Mark
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 81:Issue 4(2010)
• Page Start: 423
• Page End: 427
• Publication Date: 2009-12-03
• Subjects: Spasticity -- upper limb -- kinematics -- Botulinum Toxin -- rehabilitation -- stroke; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.2009.188052
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Background: Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods: Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results: Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions: Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.