AB0946 Association of Cognitive Function with Serum Uric Acid and Mean Platelet Volume Levels Between Fibromyalgia Syndrome and Healthy Subjects. (9th June 2015) - Vural, M.
Abstract : Background: Studies have shown moderate cognitive impairment in patients with Fibromyalgia syndrome (FMS). Mean platelet volume (MPV), a marker of platelet activation. Activated platelets may play role in neuroinflammation and cognitive dysfunction. In addition, recent clinical studies identified the relation between uric acid (UA) and cognitive impairment in neurological diseases. Objectives: Our aim was to compare the serum UA and MPV levels between FMS patients and control subjects and to investigate the relationship between UA, MPV and cognitive impairment in patients with FMS. Methods: A total of 54 premenopausal female patients with FMS diagnosed according to 1990, 2010 and 2013 ACR criteria referring to Physical Medicine and Rehabilitation outpatient clinic and 33 volunteer healthy control matched according to their ages and genders were enrolled. Visual Analog Scale (VAS), to assess pain and sleep quality, and Fibromyalgia Impact Questionnaire (FIQ), to evaluate the functional status, were used in both groups. We assessed the psychological status with Beck Depression Inventory (BDI) and the frequency of cognitive impairment was evaluated with Mini Mental State Examination (MMSE). Serum MPV, platelet and UA levels were measured. Results were evaluated considering the significance level p<0.05. Results: No statistically significant difference was observed demographic characteristics between FMS and control groups (p>0.05). Mean VAS pain and sleep quality of FMS group were determined significantly higher than control group (p<0.05). Significant differences were found in FIQ and BDI scores of FMS patients compared to controls (p<0.05). The mean of MMSE score was statistically significantly lower than control group (p<0.05). No statistically significant difference was observed in MPV, platelet and UA between FMS and control groups (p>0.05). No significant correlation was determined between serum UA levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05). Similarly, no significant correlation was found between serum MPV levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05). Conclusions: Our results suggest that there were no association between serum UA, MPV and cognitive impairment levels in FMS patients in comparison to control subjects. Many variables, such as age, pain, depression and poor functional status, likely contribute to the cognitive impairment in FMS. References: Koç ER, Uzar E, Çirak Y, Parlak Demir Y, Ilhan A. The increase of mean platelet volume in patients with Alzheimer disease. Turk J Med Sci 2014;44(6):1060-6. Vannorsdall TD, Kueider AM, Carlson MC, Schretlen DJ. Higher baseline serum uric acid is associated with poorer cognition but not rates of cognitive decline in women.Exp Gerontol. 2014;60:136-9. Cicero AF, Desideri G, Grossi G, Urso R, Rosticci M, D'Addato S, Borghi C; The Brisighella Heart Study Group. Serum uric acid and impaired cognitive function in a cohort of healthy young elderly: data from the Brisighella Study. Intern Emerg Med 2014 Jul 2. Haliloğlu S, Carlioglu A, Sahiner E, Karaaslan Y, Kosar A. Mean platelet volume in patients with fibromyalgia. Z Rheumatol 2014;73(8):742-5. Disclosure of Interest: None declared