FRI0209 Gender-Specific Clinical Features of Early Axial Spondyloarthritis. (9th June 2015)

• Record Type: Journal Article
• Authors: Gubar, E.; Dubinina, T.; Dyomina, A.; Godzenko, A.; Rumyantseva, O.; Shubin, S.; Smirnov, A.; Glukhova, S.; Erdes, S.
• Is Part Of: Annals of the rheumatic diseases. Volume 74(2015)Supplement 2
• Page Start: 500
• Page End: 500
• Publication Date: 2015-06-09
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2015-eular.3203
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To analyze gender-specific clinical features of patients with early axSpA. Methods: 150 patients with axSpA and <5 years duration of inflammatory back pain (ASAS criteria) were examined. Patients fulfilled ASAS criteria and were examined according to ASAS guidelines. Results: The Russian cohort of 150 axSpA patients included 59 (39.3%) men and 91 (60.7%) women. The women were significantly older: the median age of men was 25 (23-27), the age of women – 30 (26-34) ( p =0.000001). Men were more often HLA B27 - positive (88% vs 75%; p =0.048). At the first examination, males more often than females had X-ray identified sacroiliitis (xSI): 65.5% vs 42.9% ( p =0.007), and their AS was determined by the mNY criteria. Acute phase inflammation reactants (ESR and CRP) were significantly higher in men. Median ESR was 13 (6-32) mm/h in men, and 8 (5-15) mm/h – in women ( p =0.02); median CRP 16. 7 (1.7-63.3) mg/L and 2.4 (0.9-7.8) mg/L, respectively ( p =0.00004). Calcaneal enthesopathy (US examination) was significantly more often present in men (55.1%), than in women (32.1%; p =0.01). There was no statistically significant difference between men and women in terms of BASDAI and ASDAS activity indexes, presence of peripheral arthritis, coxitis, dactilitis, MRI-sacroiliitis, MRI-spondylitis, low BMD, BASFI functional index, family SpA history. Conclusions: In the Russian cohort of axSpA patients, males seem to have a more aggressive disease than females: they have an earlier onset of axSpA, and earlier develop destructive changes in sacroiliac joints. Men are more often HLA B27 – positive. Calcaneal enthesopathy (US-examination) is more common in men. Acute phase reactants (ESR and CRP) are higher in men than in women. Functional BASFI status was similar in both genders. Disclosure of Interest: None declared