Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Clemons, Joseph; Jandu, Arvinder; Stein, Brandon; Chary, Michael A.
• Is Part Of: Toxicology communications. Volume 5:Issue 1(2021)
• Page Start: 15
• Page End: 18
• Publication Date: 2021-01-01
• Subjects: Intravenous lipid emulsion -- toxicity -- diphenhydramine -- overdose -- hypotension -- resuscitation; Toxicology -- Periodicals; 615.9005
• DOI: 10.1080/24734306.2020.1870078
• Languages: English
• ISSNs: 2473-4306

Abstract

Abstract: Diphenhydramine (DPH) is a lipophilic inverse agonist at the histamine receptor. Overdoses usually present with anticholinergic symptoms. Wide-complex tachycardia decompensating into cardiovascular collapse may occur in larger overdoses. Here we report a patient who developed ventricular dysrhythmias after ingestion of 83 mg/kg of diphenhydramine, went into cardiovascular collapse that was rescued with early administration of intravenous lipid emulsion.