Characteristics and Outcome of SARS-CoV-2 Infection in Cancer Patients. Issue 1 (6th January 2021)

• Record Type: Journal Article
• Authors: Basse, Clémence; Diakite, Sarah; Servois, Vincent; Frelaut, Maxime; Noret, Aurélien; Bellesoeur, Audrey; Moreau, Pauline; Massiani, Marie-Ange; Bouyer, Anne-Sophie; Vuagnat, Perrine; Malak, Sandra; Bidard, François-Clément; Vanjak, Dominique; Kriegel, Irène; Burnod, Alexis; Bilger, Geoffroy; Ramtohul, Toulsie; Dhonneur, Gilles; Bouleuc, Carole; Cassoux, Nathalie; Paoletti, Xavier; Bozec, Laurence; Cottu, Paul
• Is Part Of: JNCI cancer spectrum. Volume 5:Issue 1(2021)
• Publication Date: 2021-01-06
• DOI: 10.1093/jncics/pkaa090
• Languages: English
• ISSNs: 2515-5091

Abstract

Abstract: Background: Concerns have emerged about the higher risk of fatal coronavirus disease 2019 (COVID-19) in cancer patients. In this article, we review the experience of a comprehensive cancer center. Methods: A prospective registry was set up at Institut Curie at the beginning of the COVID-19 pandemic. All cancer patients with suspected or proven COVID-19 were entered and actively followed for 28 days. Results: Among 9842 patients treated at Institut Curie between March 13 and May 1, 2020, 141 (1.4%) were diagnosed with COVID-19, based on reverse transcription polymerase chain reaction testing and/or computerized tomography scan. In line with our case mix, breast cancer (40.4%) was the most common tumor type, followed by hematological and lung malignancies. Patients with active cancer therapy or/and advanced cancer accounted for 87.9% and 68.9% of patients, respectively. At diagnosis, 78.7% of patients had COVID-19–related symptoms, with an extent of lung parenchyma involvement inferior to 50% in 95.8% of patients. Blood count variations and C-reactive protein elevation were the most common laboratory abnormalities. Antibiotics and antiviral agents were administered in 48.2% and 6.4% of patients, respectively. At the time of analysis, 26 patients (18.4%) have died from COVID-19, and 100 (70.9%) were cured. Independent prognostic factors at the time of COVID-19 diagnosis associated with death or intensive care unit admission were extent of COVID-19 pneumonia and decreased O2 saturation. Conclusions: COVID-19 incidence and presentation in cancer patients appear to be very similar to those in the general population. The outcome of COVID-19 is primarily driven by the initial severity of infection rather than patient or cancer characteristics.