A Practical Guide to Measuring Ex vivo Joint Mobility Using XROMM. Issue 1 (12th November 2020)

• Record Type: Journal Article
• Authors: Manafzadeh, Armita R
• Is Part Of: Integrative organismal biology. Volume 2:Issue 1(2020)
• Publication Date: 2020-11-12
• Subjects: Biology -- Periodicals; 570
• DOI: 10.1093/iob/obaa041
• Languages: English
• ISSNs: 2517-4843

Abstract

Synopsis: X-Ray Reconstruction of Moving Morphology (XROMM), though traditionally used for studies of in vivo skeletal kinematics, can also be used to precisely and accurately measure ex vivo range of motion from cadaveric manipulations. The workflow for these studies is holistically similar to the in vivo XROMM workflow but presents several unique challenges. This paper aims to serve as a practical guide by walking through each step of the ex vivo XROMM process: how to acquire and prepare cadaveric specimens, how to manipulate specimens to collect X-ray data, and how to use these data to compute joint rotational mobility. Along the way, it offers recommendations for best practices and for avoiding common pitfalls to ensure a successful study.